Abstract
An extremely rare case of esophageal metastasis from prostate cancer is reported. A 65-year-old man presented with anorexia and back pain. Upper gastrointestinal X-ray fluoroscopy and endoscopy revealed a shallow longitudinal ulcer, with converging mucosal folds, approximately 5 cm above the esophagogastric junction. The histological diagnosis of the biopsied specimen was adenocarcinoma. Blood biochemistry revealed elevated serum prostatespecific antigen (PSA) and γ-seminoprotein levels. Ultrasonography of the prostate disclosed a hypoechoic lesion in the left lobe, and needle biopsy led to the diagnosis of prostatic adenocarcinoma. Since there was no finding suggestive of a primary lesion, apart from that in the prostate, we conducted reverse transcriptase-polymerase chain reaction (RT-PCR) for PSA. PSA-positive mRNA was demonstrated in the tissue of the esophageal tumor. There are three reports on metastasis to the esophagus from prostate cancer, but this is the first case of esophageal metastasis from prostate cancer without any evidence of metastasis to other organs. The importance of RT-PCR for the diagnosis of primary lesions of metastatic cancer is discussed.
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References
Gross P, Freedman LJ. Obstructive secondary carcinoma of the esophagus. Arch Pathol 1942;33:361–364.
Gore RM, Sparberg M. Metastatic carcinoma of the prostate to the esophagus. Am J Gastroenterol 1982;77:358–359.
Eaves R, Lambert J, Rees J, et al. Achalasia secondary to carcinoma of prostate. Dig Dis Sci 1983;28:278–284.
Deguchi T, Doi T, Ehara H, et al. Detection of micrometastatic prostate cancer cells in lymph nodes by reverse transcriptase-polymerase chain reaction. Cancer Res 1993;53:5350–5354.
Riegmann PHJ, Vliestra RJ, van der Korput JAGM, et al. Characterization of the prostate-specific antigen gene: A novel human kallikrein-like gene. Biochem Biophys Res Commun 1988;155:181–188.
Schulz P, Stucka R, Feldmann H, et al. Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. Nucleic Acids Res 1988;16:6226.
Horoszwicz JS, Leong SS, Kawinski E, et al. LNCaP model of human prostate carcinoma. Cancer Res 1983;43:1809–1818.
Suzuki H, Nagayo T. Primary tumors of the esophagus other than squamous cell carcinoma. Histologic classification and statistics in the surgical and autopsied materials in Japan. Int Adv Surg Oncol 1980;3:73–109.
Abrams HL, Spiro R, Goldstein N. Metastases in carcinoma— analysis of 1000 autopsied cases. Cancer 1950;3:74–85.
Saitoh H, Hida M, Shimbo T, et al. Metastatic patterns of prostatic cancer: Correlation between sites and number of organs involved. Cancer 1984;54:3078–3084.
Nishijima Y, Uchida K, Koiso K, et al. Clinical significance of the vertebral vein in prostate cancer metastasis. In: Karr JP, Yamanaka H (eds) Prostate cancer and bone metastasis. New York: Plenum 1992;93–100.
Anderson MF, Harell G, Secondary esophageal tumors. Am J Roentgenol 1980;135:1243–1246.
Kuriyama M. Prostate-specific antigen as a tumor marker in prostate cancer. Int J Urol 1994;1:99–113.
Gomella LG, White JL, McCue PA, et al. Screening for occult nodal metastasis in localized carcinoma of the prostate. J Urol 1993;149:776–778.
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Nakamura, T., Mohri, H., Shimazaki, M. et al. Esophageal metastasis from prostate cancer: Diagnostic use of reverse transcriptase-polymerase chain reaction for prostate-specific antigen. J Gastroenterol 32, 236–240 (1997). https://doi.org/10.1007/BF02936374
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DOI: https://doi.org/10.1007/BF02936374