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Affinity-based separations and purifications

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Abstract

The separation and purification of biologically functional molecules (e.g., proteins, antibodies, peptides, hormones, low molecular weight biologicals) is of fundamental importance to biotechnology. Affinity separations have become a particularly attractive method for bioseparations due to their high degree of selectivity. Numerous affinity ligands have been prepared in recent years including lectins, nucleic acids, inhibitors, and immunoresponse agents. Furthermore, a variety of novel supports have been synthesized to aid in the development of commercially useful affinity separation systems. Recent US patents and scientific literature on affinity separations and purifications are surveyed. Patent abstracts are summarized individually and a list of literature references are given.

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  1. Department of Chemical and Biochemical Engineering University of Iowa, Iowa 52242, Iowa City

    Jonathan S. Dordick

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Dordick, J.S. Patents and literature. Appl Biochem Biotechnol 27, 93–109 (1991). https://doi.org/10.1007/BF02921518

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