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Accessory cell-derived signals required for T cell activation

  • T Cell Activation
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Abstract

Various populations of accessory cells differ in their abilities to function as effective antigen-presenting cells (APC) and stimulate CD4+ T cells to produce interleukin-2. Three important factors directly related to APC potency are the expression of class II major histocompatibility complex molecules and the ability to present peptide antigens to the T cell antigen receptor, the expression of costimulatory ligands which deliver important activation signals independent of T cell receptor occupancy and the expression of adhesion molecules which promote conjugate formation so that these activation signals can be effectively delivered to the T cells. The relative importance of these accessory cell functions in T cell activation will be discussed, with an emphasis on costimulation and the CD28/B7 receptor/ligand pair. The consequence of inadequate costimulation by an otherwise effective APC in inducting T cell anergy will also be discussed. *** DIRECT SUPPORT *** A02GS021 00006

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  1. Department of Microbiology, University of Minnesota, 120 Delaware Street S.E. Minneapolis, Box 196 UMHC, 55455, Minneapolis, Minn., (USA)

    Julia G. Johnson & Marc K. Jenkins

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Johnson, J.G., Jenkins, M.K. Accessory cell-derived signals required for T cell activation. Immunol Res 12, 48–64 (1993). https://doi.org/10.1007/BF02918368

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