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Crystal structure of benzocaine—A local anaesthetic

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Abstract

The structure of the local anaesthetic benzocaine was solved by direct methods and refined to anR of 0·12 for 531 observed reflections. The packing of the molecule is stabilised by N−H … O hydrogen-bonds (2–97 Â). The alkyl chain attached to the benzene ring is intrans-trans conformation. The benzoic moiety shows a quinonoid character as found in some other local anaesthetics.

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Authors and Affiliations

  1. Department of Crystallography and Biophysics, University of Madras, Guindy Campus, 600 025, Madras, India

    B K Sinha & Vasantha Pattabhi

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  1. B K Sinha
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  2. Vasantha Pattabhi
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DCB contribution No. 699

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Sinha, B.K., Pattabhi, V. Crystal structure of benzocaine—A local anaesthetic. Proc. Indian Acad. Sci. (Chem. Sci.) 98, 229–234 (1987). https://doi.org/10.1007/BF02900724

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  • DOI: https://doi.org/10.1007/BF02900724

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