Summary
Isolated atrial amyloid, the most frequent senile cardiac amyloid type, was chemically analysed. Amyloid fibrils obtained from a patient (NIP) were extracted and the predominant lowmolecular-weight polypeptide (approximately 3.5 kDa, designated ASc2 NIP) was isolated by size exclusion high performance liquid chromatography in 60% formic acid. N-Terminal amino acid sequence analysis of this polypeptide was identical to that of the atrial natriuretic peptide α-hANP for the first 12 residues determined.
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Linke, R.P., Voigt, C., Störkel, F.S. et al. N-Terminal amino acid sequence analysis indicates that isolated atrial amyloid is derived from atrial natriuretic peptide. Virchows Archiv B Cell Pathol 55, 125–127 (1988). https://doi.org/10.1007/BF02896569
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DOI: https://doi.org/10.1007/BF02896569