Abstract
Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were no statistically significant differences in all the parameters studied.
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Skibber, J.M., Minsky, B.D. and Hoff, P.M. (2001) Cancer of the colon. In:Cancer: Principles and practice of oncology. Devita, V.T., Hellman, S. and Rosenberg, S.A. (Eds.). Lippincott's Williams and Wilkins, Philadelphia. Sixth edition, p. 1216.
Saroja, M., Balasenthil, S. and Nagini, S. (1999) Tissue lipid peroxidation and glutathione dependant enzyme status in patients with oral squamous cell carcinoma. Cell Biochem. Funct. 17, 213–216.
Bhuvarahamurthy, V., Balasubramanian, N., and Govindasamy, S. (1996) Effect of radiotherapy and chemoradiotherapy on circulating antioxidant system of human uterine cervical carcinoma. Mol. Cell Biochem. 158, 17–23.
Fairbanks, V.F. and Klee, G.G. (1994) Biochemical aspects of hematology In:Tietz textbook of Clinical Chemistry, Burtis, C.A. and Ashwood, E.R. (Eds.). W.B. Saunders Company. 2nd edition, 1990–1991.
Jain, S.K., Mcvie, R., Duett, J. and Herbst, J.J. (1989) Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 38, 1539–1542.
Warholm, M., Guthenberg, C., Christer von Bahr and Mannervik, B. (1985) Glutathione transferases from human liver. In:Methods of enzymology. Alton Meister (Ed.). Academic Press, Vol 113, p. 500–501.
Ahmed, M.I., Fayed, S.T., Hossei, H. and Tash, F.M. (1999) Lipid peroxidation and antioxidant status in human cervical carcinoma. Dis. Markers 15, 283–291.
Faber, M., Coudray, C., Hida, H., Mousseau, M. and Favier, A. (1995) Lipid peroxidation products and vitamin and trace element status in patients with cancer before and after chemotherapy, including adriamycin. A preliminary study. Biol. Trace Elem. Res. 47, 117–123.
Batko, J. (1997) The effect of experimental neoplastic disease on malonyldialdehyde level and glutathione status in erythrocytes of rats. Acta. Biochim. Pol. 44, 767–769.
Subapriya, R., Kumaraguruparan, R., Ramachandran, C.R. and Nagini, S. (2002) Oxidant-antioxidant status in patients with oral squamous cell carcinoma at different intraoral sites. Clin. Biochem. 35, 489–493.
Gerber, M., Astre, C., Segala, C., Saintot, M., Scall, J., Simony-Lafontaine, J., Grenier, J. and Pujol, H. (1996) Oxidant-antioxidant status alterations in cancer patients: relationship to tumor progression. J. Nutr. 126, 1201S-1207S.
Saintot, M., Astre, C., Pujol, H. and Gerber, M. (1996) Tumor progression and oxidant and antioxidant status. Carcinogenesis 17, 1267–1271.
Roy, D. and Liehr, J.G. (1989) Changes in activities of free radical detoxifying enzymes in kidneys of male Syrian hamsters treated with estradiol. Cancer Res. 49, 1475–1480.
Skrzydlewska, E., Stankiewicz, A., Sulkowska, M., Sulkowski, S. and Kasacka, I. (2001) Antioxidant status and lipid peroxidation in colorectal cancer. J. Toxicol. Environ. Health A 64, 213–222.
Polat, M.F., Taysi, S., Gul, M., Yilmax, I., Bakan, E. and Erdogan, F. (2002) Oxidant-antioxidant status in blood of patients with malignant breast tumor and benign breast disease. Cell Biochem. Funct. 20, 327–331.
Kumaraguruparan, R., Subapriya, R., Kabalimoorthy, J. and Nagini, S. (2002) Antioxidant profile in circulation of patients with fibroadenoma and adenocarcinoma of breast. Clin. Biochem. 35, 275–279.
Ozdemirler, G., Pabuccuoglu, H., Bulut, T., Bugra, D., Uysal, M. and Toker, G. (1998) Increased lipid peroxide levels and antioxidant system in colorectal cancer. J. Cancer Res. Clin. Oncol. 124, 555–559.
Sinha, B.K., Mimnaugh, E.G., Rajagopalan, S. and Myers, C.E. (1989) Adriamycin activation and oxygen free radical formation in human breast tumor cells: Protective role of glutathione peroxidase in adriamycin resistance. Cancer Res. 49, 3844–3848.
Manju, V., Kalaivani, Sailaja, J. and Nalini, N. (2002) Circulating lipid peroxidation and antioxidant status in cervical cancer patients: a case control study. Clin. Biochem. 35, 621–625.
Mukundan, H., Bahadur, A.K., Kumar, A., Sardana, S., Naik, S.L., Ray, a. and Sharma, B.K. (1999) Indian J. Exp. Biol. 37, 859–364.
Osaki, T., Ueta, E., Yoneda, K., Hirota, J. and Yamomoto, T. (1994) Prophylaxis of oral mucositis associated with chemotherapy for oral carcinoma by azelastine hydrochloride with other antioxidants. Head Neck 16, 331–339.
Colvin, O.M. (2001) Antitumor alkylating agents. In: Cancer: Principles and practice of oncology. Devita, V.T., Hellman, S. and Rosenberg, S.A. (Eds.). Lippincott's Williams and Wilkins, Philadelphia. Sixth edition, pg 369.
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Upadhya, S., Upadhya, S., Mohan, S.K. et al. Oxidant-antioxidant status in colorectal cancer patients—Before and after treatment. Indian J Clin Biochem 19, 80–83 (2004). https://doi.org/10.1007/BF02894261
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DOI: https://doi.org/10.1007/BF02894261