Summary
Very low-density lipoprotein receptor (VLDLR) is the major receptor with which cells can uptake the triacylglycerol from blood. It is divided into two subtypes according to presence of O-linked sugar domain located in the VLDLR receptor immediately outside of the membrane. Type I VLDLR contains the O-link domain, while type II has no such domain. The type I VLDLR are mainly found on the surface of human myocardial cells. The result of our quantitative polymerase chain reaction on the normal and fibrotic cardiac muscles showed that both subtypes and expression level of VLDLR on the myocardial cell surface did not vary significantly between the normal and the fibrotic cardiac muscles despite the presence of malfunction due to fibrosis. This finding suggests that fibrosis doesn’t exert significant influence on the subtype and the expression of VLDLR on the surface of myocardial cells. Such inconsistence with the changes found in other fibrotic tissues is awaiting further studies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Takahashi S, Kawarabayashi Y, Nakai Jet al. Rabbit very low-density lipoprotein receptor: a low-density lipoprotein receptor like protein with distinct ligand specificity: Proc Natl Acad Sci USA, 1992, 89: 9252
Sakai J, Hoshino A, Takahashi Set al. Structure, chromosome location, and expression of human very low-density lipoprotein receptor gene. J Biol Chem, 1994, 269: 2173
Kim D H, Lijima H, Goto Ket al. Human apolipoprotein E receptor 2: A novel lipoprotein receptor of the low density lipoprotein family predominantly expressed in brain. J Biol Chem, 1996, 271: 8373
Kim D H, Magoori K, Inoue T Ret al. Exon/intron organization, chromosome locatiolization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene. J Biol Chem, 1997, 272: 8489
Yamamoto T, Davis C G, Brown M Set al. the human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its Mrna. Cell, 1984, 39: 27
Chen W J, Goldstein J L, Brown M S. NPXY, a sequence of found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density receptor J Biol Chem, 1990, 265: 3116
Gafvels M E, Caird M, Britt Det al. Cloning of a cDNA encoding a putative human very low density lipoprotein/ apolipoprotein E receptor and assisgnment of the gene to chromosome 9ptor-p23. Somat Cell Mol Genet, 1993, 19: 557
Webb J C, Patel D D, Jones M Det al. Characterization and tissue-specific expression of the human very low density lipoprotein (VLDLR) receptor mRNA. Hum Mol Genet, 1994, 3: 531
Oka K, IshimuraOka K, Chu M Jet al. Mouse very low density lipoprotein receptor (VLDLR) Cdna cloning tissue-specific expression and evolutionary relationship with the low density lipoprotein receptor. Eur J Biochem. 1994, 224: 995
Yamamoto T and Bujo H. Close encounters with apolipoprotein E receptors. Curr Opin Lipidol, 1996, 7: 298
Lijima H, Miyazawa M, Sakai Jet al. Expression and Characterization of a very low density lipoprotein receptor variant lacking the O-link sugar region generated by alternative splicing. J Biochem (Tokyo), 1998, 124(4): 747
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Guangtian, Y., Li, B., Jinping, Z. et al. Investigation of the distribution and changes of VLDLR Subtype in fibrotic cardiac muscles. Current Medical Science 20, 297–300 (2000). https://doi.org/10.1007/BF02888184
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02888184