Summary
In this study, porcine pulmonary artery segments (intact or denuded) and bronchial segments (with or without epithelium) were tested in organ bath. Hypoxia caused a bronchial epithelium dependent relaxation of intact or denuded pulmonary artery preconstricted with phenylephrine. Constriction in intact pulmorary artery coated with epithelium denuded bronchus was observed during hypoxia. The bronchial epithelium-dependent relaxation could be inhibited by indomethacin but not be blocked by the following agents: atropine, propranolol, gossypol, methylene blue and chlorpheniramine. The results suggested tnat HPV was endothelium-dependent. Hypoxia could cause the production of an epithelium-derived relaxing factor (EpDRF), which acted directly on smooth muscle. The effect of EpDRF was not mediated by pulmonary endothelium, but might be rslated to aracnidonic acid cyclooxygenase pathway.
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Wei-han, W., Di-xun, W. The regulatory effect of substances released from porcine bronchial epithelial cells on hypoxic pulmonary vasoconstriction. Journal of Tongji Medical University 13, 84–87 (1993). https://doi.org/10.1007/BF02887921
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DOI: https://doi.org/10.1007/BF02887921