Summary
Spermicidal effect of Jieze No. 1 (JZ1) in combination with nonoxynol-9 (N-9) was examinedin vitro. The minimum spermicidal concentration of JZ1 decoction, N-9 and their mixture solution in 20 s and 3 min were examined by improved spermicidal test of Sander-cramerin vitro. The percentages of progressively moving spermatozoa, moving spermatozoa and viable spermatozoa were also observed 20 s, 3 min and 30 min after the addition of the liquid medicine. Our results showed that sperms did not recover their activities in a revival test when the minimum spermicidal concentration of either JZ1 decoction, or N-9, or the mixed solution of the two agents, was used. N-9 (JZ1 in the mixed group) showed significant differences in the percentages of progressively moving spermatozoa, moving spermatozoa, and visible spermatozoa in 20 s, 3 min, and 30 min, when compared with N-9 alone (P<0.01). We are led to conclude that JZ1 decoction can improve N-9 spermicidal actionin vitro, and when used in combination with N-9, it has synergic effect.
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XU Ping, female, born in 1979, Graduate Student
This project was supported by the National “10th Five-Year” Key Technologies R & D (No. 2004BA 709 B13-02).
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Ping, X., Zhuo, C., Lijun, X. et al. Spermicidal effect of jieze No. 1 in combination with nonoxynol-9In vitro. Current Medical Science 25, 225–228 (2005). https://doi.org/10.1007/BF02873584
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DOI: https://doi.org/10.1007/BF02873584