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Risk factors for coronary heart disease in type II diabetes mellitus

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Abstract

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. An attempt has been made to evaluate the risk factors for coronary heart disease in type II diabetics. In the present study the levels of fasting and postprandial plasma glucose, total cholesterol, low density lipoproteins, triglycerides were high and the levels of high density lipoproteins were low in the type II diabetics compared to controls. The markers of free radical induced injury i.e. malondialdehyde and nitrite/nitrate were high while total antioxidant status a marker for antioxidant protection against reactive oxygen species was low in diabetics compared to controls. The study therefore suggests the importance of assessing these markers of oxidative stress and antioxidant capacity along with the other routine investigations in diabetic patients for initiating antioxidant therapy in addition to primary and secondary preventive measures to mitigate the devastating consequences of diabetes leading to coronary heart disease.

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Authors and Affiliations

  1. Dept. of Cell Biology, Institute of Genetics amd Hospital for Genetic Diseases, Osmania University, Begumpet, 16, Hyderabad

    H. Surekha Rani, G. Madhavi, V. Ramachandra Rao & A. Jyothy (Director)

  2. Sahay’s Diabetic Clinic and Research Centre, “My Nest” 6-3-852/A, 500 016, Ameerpet, Hyderabad

    B. K. Sahay

Authors
  1. H. Surekha Rani
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  2. G. Madhavi
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  3. V. Ramachandra Rao
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  4. B. K. Sahay
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  5. A. Jyothy
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Correspondence to A. Jyothy.

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Rani, H.S., Madhavi, G., Rao, V.R. et al. Risk factors for coronary heart disease in type II diabetes mellitus. Indian J Clin Biochem 20, 75–80 (2005). https://doi.org/10.1007/BF02867404

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