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Studies on the anti-inflammatory activity ofAralia continentalis (I)

Characterization of continentalic acid and its anti-inflammatory activity

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Abstract

By tracing albumin stabilizing activity an anti-inflammatory component, continentalic acid was isolated from ether-soluble acidic fraction ofAralia continentalis. Continentalic acid in a concentration of 0.115mg/3ml gave 50% inhibition for heat denaturation of albumin. The protein stabilizing potency of it was approximately three and eleven times that of phenylbutazone and that of salicylic acid, respectively. The anti-inflammatory actions of it and its methylester were investigated employing carrageenin-induced edema in rat paw. Continentalic acid administereds.c. showed an activity of about three times of hydrocortisone. When administeredp.o., it was still active, but its methylester was more active than phenylbutazone, suggesting the poor absorption of it in gastrointestinal tract. Its chemical structure was identified by chemical and specitral studies as (−) pimara-8(14), 15-diene-19-oic acid, which was already isolated fromA. cordata, but not reported for its biological activity.

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Authors and Affiliations

  1. Natural Products Research Institute, Seoul National University, 110, Seoul

    Byung Hoon Han, Yong Nam Han & Myung Hwan Park

  2. College of Pharmacy, Sockmyung Women's University, 140, Seoul, Korea

    Ki Ae Han & Eun Ok Lee

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  1. Byung Hoon Han
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  2. Yong Nam Han
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  3. Ki Ae Han
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  4. Myung Hwan Park
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  5. Eun Ok Lee
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Han, B.H., Han, Y.N., Han, K.A. et al. Studies on the anti-inflammatory activity ofAralia continentalis (I). Arch. Pharm. Res. 6, 17–23 (1983). https://doi.org/10.1007/BF02855697

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  • DOI: https://doi.org/10.1007/BF02855697

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