Abstract
Glutathione peroxidase is an enzyme that couples the oxidation of reduced glutathione to the detoxification of peroxides. Alterations in the activity of this component of the glutathione oxygen scavenging system in brain have been reported in several conditions associated with oxidative challenge and/or cellular damage. We measured the activity of glutathione peroxidase in autopsied brain regions of neurologically normal adults and in brain of patients with primary degenerative disorder Alzheimer’s type (AD/SDAT), as well as two other neurodegenerative disorders, namely Huntington’s disease and striatonigral degeneration. No significant alterations in enzyme activity were observed in morphologically normal or abnormal brain regions. Our results suggest that in the three brain disorders studied, the neuronal cell loss is unlikely to result from reduced activity of brain glutathione peroxidase, and that a significant compensatory increase in this brain enzyme, consequent to the degenerative processes, does not occur.
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References
Adams R. D. and Victor M. (1984)Principles of Neurology, Second Ed., pp. 794–832, McGraw-Hill, London.
Ambani L. M., van Woert M. H., and Murphy S. (1975) Brain peroxidase and catalase in Parkinson’s disease.Arch. Neurol. 30, 114–118.
Beutler A. (1971)Red cell metabolism: A manual of biochemical methods, pp. 71–73, Grune and Stratton, New York.
Brooksbank B. W. L. and Balasz R. (1983) Superoxide dismutase and lipoperoxidation in Down’s syndrome fetal brain,Lancet i, 881–882.
Chow C. K., Dillard C. J., and Tappel A. L. (1974) Glutathione peroxidase system and lysozyme in rats exposed to ozone or nitrogen dioxide.Environ. Res. 7, 311–319.
Cohen G. (1983) The pathobiology of Parkinson’s disease: biochemical aspects of dopamine neuron senescence.J. Neural Transm. Suppl. 19, 89–103.
Forman H. J. and Fisher A. B. (1984) Role of glutathione peroxidase in tolerance and adaptation of rats to hyperoxia, inOxygen Radicals in Chemistry and Biology (Boro W., Savan M., and Tait P., eds.), pp. 699–705, Walter de Gruyter, Berlin.
Halliwell B. and Gutteridge J. M. C. (1985) Oxygen radical and the nervous system.Trends in Neurosci. January, pp. 22–26.
Harman D. (1984) Free radical theory of aging: the “free radical” diseases.Age 7, 111–131.
Kaplan E., Bigelow D., Vatassery G., and Ansari K. (1982) Glutathione peroxidase in human cerebrospinal fluid.Brain Res. 252, 391–393.
Kish S. J., Morito C., and Hornykiewicz O. (1985) Glutathione peroxidase activity in Parkinson’s disease brain.Neurosci. Lett. 58, 343–346.
Marklund S. L., Adolfsson R., Gottfries C. G., and Winblad B. (1985) Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type.J. Neurolog. Sci. 67, 319–325.
Mizuno Y. (1984a) Changes in superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities and thiobarbituric acid—reactive products levels in early stages of development in dystrophic chickens.Environ. Neurol. 84, 58–73.
Mizuno Y. (1984b) Studies on the pathogenesis of degenerative neurological disorders.Rinsho Shinkeigaku 24, 118–124.
Paglia D. E. and Valentine W. N. (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.J. Lab. Clin. Med. 70, 158–169.
Perry T. L., Godin D. V., and Hansen S. (1982) Parkinson’s disease: a disorder due to nigral glutathione deficiency?Neurosci. Lett. 33, 305–310.
Sinet P. M. (1982) Metabolism of oxygen in Down’s syndrome.Ann. NY Acad. Sci. 396, 83–94.
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Kish, S.J., Morito, C.L.H. & Hornykiewicz, O. Brain glutathione peroxidase in neurodegenerative disorders. Neurochemical Pathology 4, 23–28 (1986). https://doi.org/10.1007/BF02834296
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DOI: https://doi.org/10.1007/BF02834296