Abstract
Various low molecular weight chitosans were prepared by oxidative degradation with H2O2, and characterized by IR,13C-NMR and gel permeation chromatography. Their carboxylic contents increased with decrease in molecular weight (M w ). The antitumor test of the samples against sarcoma 180 tumors suggested that the water-soluble chitosan with higherM w have higher inhibitory ratioin vivo. The introduction of carboxylic group is advantage to water-solubility of chitosan, but more acidic groups might decrease the function of amino groups of chitosan against sarcoma 180 tumor.
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References
Kumar M N V R. A Review of Chitin and Chitosan Applications.Reactive & Functional Polymers, 2000,46: 1–27.
Shahidi F, Arachchi J K V, Jeon Y J. Food Applications of Chitin and Chitosans.Trends in Food Science & Technology, 1999,10: 37–51.
Dodane V, Vilivalam V D. Pharmaceutical Applications of Chitosan.Pharmaceutical Science & Technology today, 1998,1: 246–253.
Koide S S. Chitin-Chitosan: Properties, Benefits and Risks.Nutrition Research, 1998,18(6): 1091–1101.
Suzuki K, Mikami T, Okawa Y,et al. Antitumor Effect of Hexa-N-acetyl Chitohexaose and Chitohexaose.Carbohydrate Research, 1986,151: 403–408.
Zhu Q, Sjoholm R, Nurmi K, Bertoft E. Structural Characterization of Oxidized Potato Starch.Carbohydr Res, 1998,309: 213–218.
Qin C Q, Xiao L, Du Y M. Prediction and Control of Extent of Deploymerization of Chitosan by Hydroperoxide.J Wuhan Univ (Nat Sci Ed) 2000,46(2): 19–22 (Ch).
Jeon Y J, Kim S K. Production of Chitooligosaccharides Using an Ultrafiltration Membrane Reactor and their Antibacterial Activity.Carbohydr Polym, 2000,41: 133–141.
Chen L Y, Du Y M, Xiao L, Qin C Q. Studies on the Substitution of Carboxymethyl Chitosan and Its Moisture-retention Capacity.Chinese J Appl Chem, 2001,18(1): 7–10.
Tokura S, Itoyama K, Ninhi N. Selective Sulfation of Chitin Derivatives for Biomedical Functions.J M S-Pure Appl Chem, 1994,A31(11): 1701–1718.
Onishi H, Machida Y. Biodegradation and Distribution of Water-Soluble Chitosan in Mice.Biomaterimals, 1999,20: 175–182.
Tokoro A, Tatewaki N, Suzuki K,et al. Growth-inhibitory Effect of Hexa-N-AcetylChitohexaose and Chitohexaose Against Meth-A Solid Tumor.Chem Pharm Bull, 1988,36(2): 780–790.
Seo W G, Pae H O, Kim N Y,et al. Synergistic Cooperation between Water-soluble Chitosan Oligomers and Interferon-γ for Induction of Nitric Oxide Synthesis and Tumoricidal Activity in Murine Peritoneal Macrophages.Cancer Letters, 2000,159: 189–195.
Muzzarelli R A A.Chitin. Oxford: Pergamon Press, 1977, 257.
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Foundation item: Supported by the National Natural Science Foundation of China (No. 29977014)
Biography: Qin Cai-qin (1965-), male, Ph. D candidate, Associate professor, research direction: biopolymers.
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Cai-qin, Q., Yu-min, D., Ling, X. et al. Effect of molecular weight and structure on antitumor activity of oxidized chitosan. Wuhan Univ. J. Nat. Sci. 7, 231–236 (2002). https://doi.org/10.1007/BF02830325
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DOI: https://doi.org/10.1007/BF02830325