Abstract
The superoxide scavenging activities of 12 flavonoids were measured. The superoxide anions were generated by a hypoxanthine-xanthine oxidase system and measured by the nitrite method. The results showed that the scavenging ability enhanced with an increasing number of hydroxyl groups in rings B. Substitution at C3 position with a hydroxyl group increased the activity. Compared to a methoxyl group or a glycoside in this position, a free hydroxyl group showed the highest activity. A saturated C2−C3 bond showed a higher activity than a unsaturated bond. The absence of a carbonyl group at C4 position increased the activity.
Similar content being viewed by others
References
B. Havsteen,Biochem. Pharmacol. 32, 1141–1148 (1983).
Y. T. Chen, R. L. Zheng, Z. J. Jia, and Y. Ju,Free Radic. Biol. Med. 9, 19–21 (1990).
G. Sichel, C. Corsaro, M. Scalla, A. J. Di Bilio, and R. P. Bonomo,Free Radic. Biol. Med. 11, 1–8 (1991).
T. Yoshida, K. Mori, T. Hatano, T. Okumura, I. Uehara, K. Komagoe, Y. Fujita, and T. Okuda,Chem. Pharm. Bull. 37, 1919–1921 (1989)
N. Cotelle, J. L. Bernier, J. P. Henichart, J. P. Catteau, E. Gaydou, and J. C. Wallet,Free Radic. Biol. Med. 13, 211–219 (1992).
Y. Oyanagui,Anal. Biochem. 142, 290–296 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hu, J.P., Calomme, M., Lasure, A. et al. Structure-activity relationship of flavonoids with superoxide scavenging activity. Biol Trace Elem Res 47, 327–331 (1995). https://doi.org/10.1007/BF02790134
Issue Date:
DOI: https://doi.org/10.1007/BF02790134