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Zinc bone loss in chronic renal failure and chronic metabolic acidosis

  • Part 2: Trace elements in endocrinology
  • Section 4: Kidneys, Adrenals, and Corticosteroid Hormones
  • Published:
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Abstract

The effects of chronic metabolic acidosis (CMA) on zinc (Zn) bone content and urinary excretion were examined in the presence of normal or reduced renal function together with some aspects of calcium (Ca) metabolism. Four groups of rats were compared. All were fed a 30% protein and 9 mg Zn/100 g diet. Two were uremic (U): The first developed acidosis (UA), which was suppressed in the other (UNA) by NaHCO3 supplement. Two other groups had normal renal function: One was normal (CNA), and the other had NH4Cl in the drinking water and acidosis (CA).

Femur total Zn and Ca content was markedly reduced by CMA and was not affected by uremia. Zn urinary excretion was increased by CMA and unaltered by uremia. Ca urinary excretion was markedly reduced in uremic rats, but was enhanced in both acidotic conditions. Urinary Ca and Zn showed a strong correlation in uremic and in control rats. Plasma parathormone and 1,25(OH)2D3 were unchanged by CMA. These data are in agreement with a direct primary effect of CMA on bone in releasing buffers. CMA induces bone resorption and a parallel decrease of mineral bone components, such as Ca and Zn, with little or no role of PTH, 1,25(OH)2D3 and of uremia itself.

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Authors and Affiliations

  1. INSERM U.192, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, France

    Alberto Caldas, Saad Maniar, Denise Laouari, Michele Dechaux & Claire Kleinknecht

  2. Laboratoire de Biochimie C, Hôpital Nord, BP. 217 X, 38043, Grenoble, France

    Marie Jeanne Richard & Alain Favier

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  1. Alberto Caldas
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Caldas, A., Richard, M.J., Maniar, S. et al. Zinc bone loss in chronic renal failure and chronic metabolic acidosis. Biol Trace Elem Res 32, 339–348 (1992). https://doi.org/10.1007/BF02784620

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  • DOI: https://doi.org/10.1007/BF02784620

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