Abstract
Lipid peroxy radicals (ROO-) were detected by electron spin resonance (ESR) at low temperature after formation by addition of H2O2 into a suspension of mice lymphocites. If lymphocytes were treated with selenomethionine (Se-Met) prior to addition of H2O2, ROO-formation was inhibited in a fashion that was dependent on Se-Met concentration. Formation of ROO- in the spleen of mice was induced by60Co irradiation. Animals that were supplemented with Na2SeO3 prior to irradiation exhibited a lower ROO-concentration than that of nontreated animals. Based on our experiments, we have concluded that Se has an oxygen-free radical scavenging effect. This should be a protective effect against lipid peroxy radical cellular attack.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. Kiremidijan-Schumacher and G. Stotzky, Selenium and immune responses,Environ. Res. 42, 277–303 (1987).
E. Sun, H. Xu, Q. Liu, J. Zhou, P. Zuo, and J. Wang, The mechanism for the effect of selenium supplementation on immunity,Biol. Trace Element Res. 48, 231–238 (1995).
E. Sun, H. Xu, Q. Liu, J. Zhou, P. Zuo, and J. Wang, Effect of selenium in recovery of immunity damaged by H2O2 and60Co radiationBiol. Trace Element Res. 48, 239–250 (1995).
K. Schwarz and A. Fredga, Biological potency of organic selenium compounds. 1. Aliphatic monoseleno and diselenodicarboxylic acids,J. Biol. Chem. 244, 2103–2110 (1969).
H. Xu, L. Zhang, E. Sun, and H. Fan, Studies on the interaction of trace element selenium with oxygen free radicals,Adv. Free Radical Biol. Med. 1, 35–48 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sun, E., Xu, H., Wen, D. et al. Inhibition of lipid peroxidation. Biol Trace Elem Res 59, 87–92 (1997). https://doi.org/10.1007/BF02783233
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02783233