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Serotonergic-cholinergic neurotransmitters’ function in brain during cadmium exposure in protein restricted rat

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Abstract

Daily subcutaneous injection of cadmium chloride (0.3 mg/100g bw) for two weeks to normal and protein restricted (5% casein) rats shows significant decrease in 5-HT concentration in cerebellum, medulla oblongata-pons, hypothalamus, striatum-hippocampus, midbrain-thalamus-subthalamus, and cortex in both dietary regimens. No significant change occurs in concentration of ACh in cerebellum, but there is a significant increase in cortex, whereas significant decrease occurs in rest of the discrete regions of brain in both dietary conditions. Results also indicate that the intensity of cadmium effect is more evident in discrete brain regions in protein restricted dietary condition than in the normal group. The inhibitory action of Cd on both neurotransmitters has been discussed.

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Author notes

  1. C. D. Dey

    Present address: Department of Physiology, Calcutta University College of Science and Technology, 92 Acharyya Prafulla Chandra Road, 700009, Calcutta, India

Authors and Affiliations

  1. Department of Microbiology, Howard University Cancer Center, 2041 Georgia Avenue NW, 20060, Washington, DC

    Kaberi P. Das

  2. Department of Oncology, Howard University Cancer Center, 2041 Georgia Avenue NW, 20060, Washington, DC

    Parikshit C. Das

  3. Department of Physiology, Calcutta University College of Science and Technology, 92 Acharyya Prafulla Chandra Road, 700009, Calcutta, India

    Shakuntala Dasgupta

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  1. Kaberi P. Das
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  3. Shakuntala Dasgupta
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  4. C. D. Dey
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Das, K.P., Das, P.C., Dasgupta, S. et al. Serotonergic-cholinergic neurotransmitters’ function in brain during cadmium exposure in protein restricted rat. Biol Trace Elem Res 36, 119–127 (1993). https://doi.org/10.1007/BF02783170

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  • DOI: https://doi.org/10.1007/BF02783170

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