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Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice

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Summary

A mouse monoclonal antibody (MoAb), S74 against a human scirrhous gastric carcinoma cell line was developed. The radioiodinated antibody bound preferentially in vivo to xenografted tumors rather than to normal tissue, whereas tumor uptake of normal mouse IgG did not occur. Thus this MoAb was able to selectively localize a human tumor in an animal model, and clinically it may enable immunotherapy against scirrhous carcinoma of the stomach.

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Authors and Affiliations

  1. First Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, 602, Kyoto, Japan

    Takashi Yokota M.D, Toshio Takahashi M.D., Toshiharu Yamaguchi M.D., Eigo Otsuji M.D., Kiyoshi Sawai M.D., Shozo Kitai M.D, Kazuya Kitamura M.D., Akinori Noguchi M.D. & Tatsuyuki Ahn M.D.

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  1. Takashi Yokota M.D
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  2. Toshio Takahashi M.D.
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  3. Toshiharu Yamaguchi M.D.
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  4. Eigo Otsuji M.D.
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  5. Kiyoshi Sawai M.D.
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  6. Shozo Kitai M.D
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  7. Kazuya Kitamura M.D.
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  8. Akinori Noguchi M.D.
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  9. Tatsuyuki Ahn M.D.
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Yokota, T., Takahashi, T., Yamaguchi, T. et al. Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice. Gastroenterol Jpn 22, 698–702 (1987). https://doi.org/10.1007/BF02776741

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  • DOI: https://doi.org/10.1007/BF02776741

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