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Effect of intracerebroventricular injection of vasoactive intestinal polypeptide on systemic blood pressure and pancreatic and gastric secretions in the rat

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Summary

In order to examine the role of vasoactive intestinal polypeptide (VIP) in systemic blood pressure and pancreatic and gastric secretions in rats, the peptide was given to rats either intravenously (i.v.) through the femoral vein or intracerebroventricularly (i.c.v.) through the lateral ventricle. VIP, when given i.V., showed a systemic, hypotensive effect and a stimulatory effect on pancreatic secretion in urethane-anesthetized rats. When VIP was given i.c.v., there was no change in systemic blood pressure and pancreatic secretion in urethane-anesthetized rats, nor in gastric secretion both in urethane-anesthetized, stomach-perfused rats and in conscious, chronic gastric fistula rats. More research is needed to determine the central effect of VIP in digestive secretion.

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Authors and Affiliations

  1. First Department of Internal Medicine, Faculty of Medicine, Kyoto University, 54 Shogoin-kawaramachi, Sakyo-ku, 606, Kyoto, Japan

    Kazuhiko Mizuta M.D., Motoyuki Moriga M.D., Hiroaki Narusawa M.D. & Haruto Uchino M.D.

  2. Department of Clinical Nutrition, Faculty of Medicine, Kyoto University, 606, Kyoto, Japan

    Mitsuru Aono M.D.

Authors
  1. Kazuhiko Mizuta M.D.
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  2. Motoyuki Moriga M.D.
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  3. Hiroaki Narusawa M.D.
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  4. Haruto Uchino M.D.
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  5. Mitsuru Aono M.D.
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Additional information

This study was supported in part by grant from the Japanese Ministry of Education, Science and Culture (to M. Moriga) (No. 59570300).

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Mizuta, K., Moriga, M., Narusawa, H. et al. Effect of intracerebroventricular injection of vasoactive intestinal polypeptide on systemic blood pressure and pancreatic and gastric secretions in the rat. Gastroenterol Jpn 21, 55–61 (1986). https://doi.org/10.1007/BF02775941

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  • DOI: https://doi.org/10.1007/BF02775941

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