Summary
The relationship between histopathological alterations and G-cell population in the stomach was studied in 14 resected stomachs from patients with chronic peptic ulcer disease (6 with duodenal ulcer and 8 with gastric ulcer). G-cells were identified by indirect immunoperoxidase method. When atrophy was graded three steps (0, 1, 2), the average grade of DU and GU was 0.23 and 0.89, respectively. There was a significant correlation (r=-0.871, p<0.005) between atrophic grade and G-cell population in each stomach. The mean occupation rate with intestinal metaplasia was 0.9% in DU and 35.8% in GU. There was no correlation between total pyloric area and G-cell population, however residual pyloric area excluding intestinal metaplasia correlated significantly with G-cell population (r=0.557, p<0.05). There was a significant difference in the mean G-cell population which were 26.5 millions in DU and 8.9 millions in GU. The mean integrated gastrin response to Cimetidine-OXO test meal were 559±236 pg/ml in DU and 216±124 pg/ml in GU, and there was significant correlation (r=0.889, p<0.005) between G-cell population and integrated gastrin response. The average age of both groups, however, was 27.7 in DU and 52.8 in GU, so that these differences of G-cell population and functional G-cell mass in both groups might originate in the histopathological alterations accompanying with the aging.
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References
Asnaes S, et al: Antral gastrin cells. A correlation between the number of gastrin cells and the total concentration of gastrin in serum and in antral mucosa. A pilot investigation. Scand J Gastroent 11: 471–474, 1976
Polak JM, et al: Studies on gastric D cell pathology. Gut 17:400–401, 1976
Creutzfeldt R, et al: Mucosal gastrin concentration, molecular form of gastrin, number and ultrastructure of G-cells in patients with duodenal ulcer. Gut 17: 745–754, 1976
Stave R, et al: Immunohistochemical investigation of gastrin-producing cells (G cells). Scand J Gastroent 11: 705–712, 1976
Stave R, et al: Quantification of gastrin-producing cells (G cells) and parietal cells in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease. Scand J Gastroent 13:747–757, 1978
Royston CMS, et al: G cell population of the gastric antrum, plasma gastrin, and gastric acid secretion an patients with and without duodenal ulcer. Gut 19: 689–698, 1978
Keuppens F, et al: Estimation of the antral and duodenal gastrin cell population removed by gastrectomy from patients with peptic ulcer. Surg Gynec Obstet 146:400–406, 1978
Ganguli PC, et al: Antral-gastrin cell hyperplasia in peptic ulcer disease. Lancet 1: 583–586, 1974
Fujimoto S, et al: A study on identification of gastrin cell with indirect immunoperoxidase method. Jpn J Gastroenterol 76: 257–264, 1978
Fujimoto S, et al: Tritiated thymidine autoradiographic study on origin and renewal of gastrin cells in pyloric area of hamsters. Gastroenterology 76: 1136, 1979
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Fujimoto, S., Kimoto, K., Inokuchi, H. et al. G-Cell population and serum gastrin response to cimetidine-oxo test meal in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease. Gastroenterol Jpn 15, 101–107 (1980). https://doi.org/10.1007/BF02774921
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DOI: https://doi.org/10.1007/BF02774921