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Severe hepatitis during ketoconazole therapy

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Summary

Ketoconazole is an imidazole derivative recently developed as an antifungal agent. There have been only a few established cases of hepatotoxicity in the literature. This report describes a case of presumed ketoconazole hepatotoxicity characterized by the development of severe hepatitis with marked centrilobular necrosis. The lack of hypersensitivity reactions in clinical findings and centrilobular location of necrosis suggested a host idiosyncrasy with metabolic abnormality as the effect of ketoconazole in the present case.

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Authors and Affiliations

  1. First Department of Medicine and Department of Dermatology, Nippon Medical School, Tokyo, Japan

    Hidemasa Okumura M.D., Takumi Aramaki M.D., Katsuaki Satomura M.D., Kazuhiro Iizuka M.D., Masao Ohta M.D., Yasumi Katsuta M.D., Masahiro Akaike M.D., Hideo Terada M.D. & Toshio Kusunoki M.D.

  2. 1st Department of Medicine, Nippon Medical School, 1-1-5 Sendagi, 113, Bunkyo-ku, Tokyo, Japan

    Hidemasa Okumura M.D.

Authors
  1. Hidemasa Okumura M.D.
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  2. Takumi Aramaki M.D.
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  3. Katsuaki Satomura M.D.
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  4. Kazuhiro Iizuka M.D.
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  5. Masao Ohta M.D.
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  6. Yasumi Katsuta M.D.
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  7. Masahiro Akaike M.D.
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  8. Hideo Terada M.D.
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  9. Toshio Kusunoki M.D.
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Okumura, H., Aramaki, T., Satomura, K. et al. Severe hepatitis during ketoconazole therapy. Gastroenterol Jpn 18, 142–147 (1983). https://doi.org/10.1007/BF02774689

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  • DOI: https://doi.org/10.1007/BF02774689

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