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Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat

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Summary

The effect of somatostatin (GH-RIH) on gastric, pancreatic and biliary secretion was examined in the anesthetized rats.

Intraveous infusion of the hormone, in graded doses ranging from 1 to 16 µg/kg/hr, produced a dose-dependent inhibition of pentagastrin, 1.5 µg/kg/hr, induced acid secretion, reaching about 54% of control level at the dose of 16 µg/kg/hr. Somatostatin, 4, 16 and 64 µg/kg/hr, inhibited the pancreatic juice volume stimulated by intravenous injection of secretin, 1 µ/kg, as a bolus. Somatostatin, 2, 8, 32 and 128 µg/kg/30 min, did not change the bile flow rate in control period. Somatostatin may play a physiological role in the regulation of the secretory process of the stomach and pancreas.

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Authors and Affiliations

  1. 1st Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kawaramachi, Shogoin, Sakyo-Ku, 606, Kyoto, Japan

    Motoyuki Moriga M.D., Koichi Kojima M.D., Mitsuru Aono M.D. & Haruto Uchino M.D.

  2. Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, 606, Kyoto, Japan

    Haruaki Yajima M.D.

Authors
  1. Motoyuki Moriga M.D.
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  2. Koichi Kojima M.D.
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  3. Mitsuru Aono M.D.
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  4. Haruto Uchino M.D.
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  5. Haruaki Yajima M.D.
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Moriga, M., Kojima, K., Aono, M. et al. Effect of intravenous infusion of somatostatin on gastric, pancreatic and biliary secretion in the rat. Gastroenterol Jpn 13, 190–196 (1978). https://doi.org/10.1007/BF02773663

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  • DOI: https://doi.org/10.1007/BF02773663

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