Abstract
Oral antidiabetic sulfonylureas like tolbutamide and glyburide have been used to treat patients with noninsulin dependent diabetes mellitus. These agents lower blood glucose by stimulating insulin secretion from the pancreatic islets of Langerhans. A major component of this stimulation is sulfonylurea-mediated closure of the ATP-inhibited potassium channels (KATP channels) of islet β-cells. Closure of these channels leads to cell depolarization, calcium uptake, and insulin exocytosis. Progress leading up to the recent cloning of the high-affinity sulfonylurea receptor and reconstitution of the KATP channel is reviewed in this article together with new data showing that sulfonylureas may control secretion by activating a novel chloride ion channel, inhibiting an islet Na/K/ATPase or via distal stimulation of granule exocytosis by a kinase C dependent mechanism.
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Aguilar-Bryan, L., Nelson, D. A., Vu, Q. A., Humphrey, M. B., and Boyd III, A. E. (1990).J. Biol. Chem. 265, 8218–8224.
Aguilar-Bryan, L., Nichols, C. G., Rajan, A. S., Parker, C., and Bryan, J. (1992).J. Biol. Chem. 267, 14934–14940.
Aguilar-Bryan, L., Nichols, C. G., Wechsler, S. W., Clement, J. P., Boyd III, A. E., Gonzalez, G., Herrera-Sosa, H., Nguy, K., Bryan, J., and Nelson, D. A. (1995).Science 268, 423–425.
Aguilar-Bryan, L. and Bryan, J. (1996).Diabetes Reviews (in press).
Ammala, C., Ashcroft, F. M, and Rorsman, P. (1993).Nature 363, 356–358.
Ammala, C., Moorhouse, A., Gribble, F., Ashfield, R., Proks, P., Smith, P. A., Sakura, H., Coles, B., Ashcroft, S. J. H., and Ashcroft, F. M. (1996).Nature 379, 545–548.
Arkhammer, P., Nilsson, T., Rorsman, P., Berggren, P. O. (1987).J. Biol. Chem. 262, 5448–54.
Ashcroft, F. M., Harrison, D. E., and Ashcroft, S. J. H. (1984).Nature 312, 446–448.
Ashcroft, F. M., Kakei, M., Gibson, J. S., Gray, D. W., and Sutton, R. (1989).Diabetologia 32, 591–598.
Ashcroft, F. M. and Rorsman, P. (1989).Biochem. Transact. 18, 109–111.
Ashcroft, F. M. and Rorsman, P. (1995). In:The electrophysiology of neuroendocrine cells. Scherubl, H. and Hescheler, J. (eds.). CRC, Boca Raton, FL. p. 208–235.
Ashcroft, F. M., Proks, P., Smith, P. A., Ammala, C., Bokvist, K., and Rorsman, P. (1994).J. Cell. Biochem. 55S, 54–65.
Ashford, M. L. J., Bond, C. T., Blair, T. A., and Adelman, J. P. (1995).Nature 370, 456–459.
Ashford, M. L. J., Bond, C. T., Blair, T. A., and Adelman, J. P. (1995).Nature 378, 792.
Best, L., Sheader, E. A., and Brown, P. D. (1996).Pflugers Archiv. 431, 363–370.
Blackard, W. G., Masatochi, K., Alexander, R., and Renold, A. E. (1975).Am. J. Physiol. 228, 706–713.
Bond, C. T., Ammala, C., Ashfield, R., Blair, T. A., Gribble, F., Khan, R. N., Lee, K., Proks, P., Rowe, I. C. M., Sakura, H., Ashford, M. J., Adelman, J. P., and Ashcroft, F. M. (1995).FEBS Lett. 367, 61–66.
Boyd III, A. E., Aguilar-Bryan, L., and Nelson, D. A. (1990).Am. J. Med. 89(suppl. 2A), 2–10.
Boyd III, A. E., Aguilar-Bryan, L., Bryan, J., Kunze, D. L., Moss, L., Nelson, D. A., Rajan, A., Raef, H., Xiang, H., and Yaney, G. C. (1991).Rec. Prog. Horm. Res. 47, 299–317.
Carpentier, J.-L., Sawano, F., Ravazzola, M., and Malaisse, W. J. (1986).Diabetologia 29, 259–261.
Chandy, K. G. and Gutman, G. A. (1993).Trends Pharm. Sci. 14, 434–436.
Cook, D. L. and Hales, C. N. (1984).Nature 311, 271–273.
Cook, D. L., Satin, L. S., Ashford, M. L. J., and Hales, C. N. (1988).Diabetes 37, 495–98.
Dunne, M. J., Illot, M. C., and Petersen, O. H. (1987).J. Membr. Biol. 99, 215–224.
Dunne, M. J. and Petersen, O. P. (1991).Biochim. Biophys. Acta 1071, 67–82.
Dunne, M. J., Kane, C., Squires, P. E., Lindley, K. J., Johnson, P. R. V., and James, R. F. L. (1995).J. Physiol. (Lond.)489P, 7S-8S.
Eliasson, L., Renstrom, E., Ammala, C., Berggren, P-O., Bertorello, A. M., Bokvist, K., Chibalin, A., Deeney, J. T., Flatt, P. R., Gabel, J., Gromada, J., Larsson, O., Lindstrom, P., Rhodes, C. J., and Rorsman P. (1996).Science 271, 813–815.
Ferrer, J., Nichols, C. G., Makhina, E. N., Salkoff, L., Bernstein, J., Gerhardt, D., Wasson, J., Ramanadhan, S., and Permutt, A. (1995).J. Biol. Chem. 44, 26,086–26,091.
Findlay, I., Dunne, M. J., and Petersen, O. P. (1985).J. Memb. Biol. 88, 165–172.
Gaines, K. L., Hamilton, S., and Boyd III, A. E. (1988).J. Biol. Chem. 263, 2589–2592.
Gembal, M., Gilon, P., and Henquin, J.-C. (1992).J. Clin. Invest. 89, 1288–1295.
Gerich, J. E. (1989).N. Engl. J. Med. 321, 1231–1245.
Gillis, K. D., Gee, W. M., Hammoud, A., McDaniel, M. L., Falke, L. C., and Misler, S. (1989).Am. J. Physiol. 257, C1119-C1127.
Gillis, K. D. and Misler, S. (1992).Pflugers Archiv. 420, 121–123.
Gylfe, E., Hellman, B., Shelin, J., and Taljedahl, I.-B. (1984).Experientia 40, 1126–1134.
Henquin, J.-C. (1990). In:New antidiabetic drugs. Bailey, C. J. and Flatt, P. R. (eds.). Smith-Gordon/Nishimura, London, UK., pp. 93–106.
Ho, K., Nichols, C. G., Lederer, W. J., Lytton, J., Vassilev, P. M., Kanazirska, M. V., and Hebert, S. C. (1993).Nature 362, 31–38.
Hopkins, W. F., Fatherazi S., Peter-Riesch, B., Corkey, B. E., and Cook, D. L. (1992).J. Membr. Biol. 129, 287–295.
Hyde, S. C., Emsley, P., Hartshorn, M. J., Mimmack, M. M., Giledi, U., Pearce, S. R., Gallagher, M. P., Gill, D. R., Hubbard, R. E., and Higgins, C. F. (1990).Nature 346, 362–365.
Inagaki, N., Tsuura, Y., Namba, N., Masuda, K., Gonoi, T., Horie, M., Seino, Y., Mizuta, M., and Seino, S. (1995a).J. Biol. Chem. 270, 5691–5694.
Inagaki, N., Gonoi, T., Clement IV, J., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., and Bryan, J. (1995b).Science 270, 1166–1169.
Khan, R. N., Hales, C. N., Ozanne, S. E., Adogu, A. A., and Ashford, M. L. J. (1993).Proc. Roy. Soc. (B)253, 225–231.
Kinard, T. A. and Satin, L. S. (1995).Diabetes 44, 1461–1466.
Krapivinsky, G., Gordon, E. A., Wickman, K., Velimirovic, B., Krapivinsky, L., and Clapham, D. E. (1995).Science 374, 135–141.
Krapivinsky, G., Krapivinsky, Velimirovic, B., Wickman, K., Navarro, B., and Clapham, D. E. (1995).J. Biol. Chem. 270, 28777–28779.
Kubo, Y., Baldwin, T. J., Jan, Y. N., and Jan, L. (1993).Nature 362, 127–133.
Kubo, Y., Reuveny, E., Slesinger, P. A., Jan, Y. N., and Jan, L. (1993).Nature 364, 802–806.
MacDonald, M. J. (1990). Diabetes39, 1461–1466.
Misler, S., Falke, L., Gillis, K. D., and McDaniel, M. L. (1986).Proc. Nat. Acad. Sci. 83, 7119–7123.
Misler, S., Gee, W. M., Gillis, K. D., Scharp, D. W., and Falke, L. (1989).Diabetes 38, 422–427.
Misler, S., Barnett, D. W., Pressel, D. M., Gillis, K., Scharp, D. W., and Falke, L. (1992).Diabetes 41, 662–670.
Nelson, D. A., Aguilar-Bryan, L., and Bryan, J. (1992).J. Biol. Chem. 267, 14,928–14,933.
Nichols, C. G., Shyng, S.-L., Nestorowicz, A., Glaser, B., Clement, J. P. IV, Gonzalez, G., Aguilar-Bryan, L., Permutt, A. M., and Bryan, J. (1996).Science (in press).
Norlund, L. and Sehlin, J. (1984).Acta. Physiol. Scand. 120, 407–415.
Panten, U., Schwanstecher, M., and Schwanstecher, C. (1992).Horm. met. Res. 24, 549–554.
Pfeifer, M. A., Halter, J. B., Judzewitsch, R. G., Beard, J. C., Best, J. D., Ward, W. K., and Porte, Jr., D. (1984).Diabetes Care 7, 25–34.
Philipson, L. H. and Steiner, D. F. (1995).Science 268, 372.
Philipson, L. H., Worley, J. F., Roe, M. W., Mittal, A., Kuznetsov, A., Blair, N. T., Ghai, K., and McIntyre, M. S. (1996).Biophys. J. 70, A361.
Porte, D., Jr. (1991).Diabetes 40, 166–180.
Proks, P. and Ashcroft, F. M. (1993).Pflugers Archiv. 424, 63–72.
Ribalet, B., Mirell, C. J., Johnson, D. G., and Levin, S. R. (1996).J. Gen. Physiol. 107, 231–241.
Ripoll, C., Lederer, W. J., and Nichols, C. G. (1993).J. Cardiovasc. Electrophysiol. 4, 38–47.
Rosman, P. and Trube, G. (1985).Pflugers Archiv. 405, 305–309.
Sakura, H., Bond, C., Warren-Perry, M., Horsley, S., Kearney, L., Tucker, A., Adelman, J., Turner, R., and Ashcroft, F. M., (1995).FEBS Lett. 367, 193–197.
Sakura, H., Ammala, C., Smith, P. A., Gribble, F. M., and Ashcroft, F. M. (1995).FEBS Lett. 377, 338–344.
Satin, L. S. and Smolen, P. D. (1994).Endocrine 2, 677–687.
Schmid-Antomarchi, H., De Weille, J. D., Fosset, M., and Lazdunski, M. (1987).J. Biol. Chem. 262, 15,840–15,844.
Sturgess, N. C., Ashford, M. L. J., Cook, D. L., and Hales, C. N. (1985).Lancet 2, 474,475.
Sui, J., Rose, P., and Logothetis, D. E. (1996).Biophys. J. 70, A309.
Thomas, P. M., Cote, G. J., Wohllk, N., Haddad, B., Mathew, P. M., Rabl, W., Aguilar-Bryan, L., Gagel, R. F., and Bryan, J. (1995).Science 268, 426–429.
Trube, G., Rorsman, P., and Ohno-Shosaku, T. (1986).Pflugers Archiv. 407, 493–499.
Tsaur, M.-L., Menzel, S., Lai, F.-P., Espinosa III, R., Concannon, P., Spielman, R. S., Hanis, C. L., Cox, N. J., Le Beau, M. M., German, M. S., Jan, L. Y., Bell, G. I., and Stoffel, M. (1995).Diabetes 44, 592–596.
Tsuura, Y., Ishida, H., Okamoto, Y., Tsuji, K., Kurose, T., Horie, M., Imura, H., Okada, Y., and Seino, Y. (1992).Diabetes 41, 861–865.
Zhang, Y., Warren-Perry, M., Sakura, H., Adelman, J., Stoffel, M., Bell, G. I., Ashcroft, F. M., and Turner, R. C. (1995).Diabetes 44, 597–600.
Zunkler, B. J., Lenzen, S., Manner, K., Panten, U., and Trube, G. (1988).Naunym Schmiedebergg's Arch. Pharmacol. 337, 225–230.
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Satin, L.S. New mechanisms for sulfonylurea control of insulin secretion. Endocr 4, 191–198 (1996). https://doi.org/10.1007/BF02738684
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DOI: https://doi.org/10.1007/BF02738684