Skip to main content
SpringerLink
Log in

Intrathecal synthesis of immunoglobulins inNeisseria meningitidis and echovirus 6 meningoencephalitis

  • Original Articles
  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

Abstract

Infectious diseases of the central nervous system (CNS) constitute the main cause of death amidst the neurological diseases in pediatric patients in Cuba. This factor, among others, made us study the immune response in children with such disorders.

Cerebrospinal fluid (CSF) and serum samples were collected from 69 patients: 26 withNeisseria meningitidis meningoencephalitis, and 43 with echovirus 6. IgA, IgM, IgG, and albumin were measured by immunodiffusion in serum and CSF. Local synthesis of immunoglobulins was calculated using Reiber’s formula.

The detection of intrathecal synthesis of IgG represents an important event in the majority of cases. Detection depends on the acuity of the process, the nature of the biologic agent and its virulence, and the immunological status of the patient. Local IgG synthesis is a very frequent finding inNeisseria meningoencephalitis and echovirus 6 meningoencephalitis. Intrathecally synthesized IgA in patients suffering fromN. meningitidis meningoencephalitis is an important indication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Dorta-Contreras A. J. and Reiber H. (1998) Intrathecal synthesis of immunoglobulins in eosinophilic meningoencephalitis due to Angiostrongylus cantonensis.Clin. Diagn. Lab. Immunol. 5, 452–455.

    PubMed  CAS  Google Scholar 

  • Dorta-Contreras A. J., García-Fernández L., and Gil-Chaviano M. (1991) Neuroimmunolab: sistema para la evaluación de la repuesta inmune en el sistema nervioso central.Rev. Cubana Invest. Biomed. 10, 155.

    Google Scholar 

  • Dorta-Contreras A. J., Ferrá-Valdés M., Torres-Romo U., Bú-Coifiu-Fanego R., García-Fernández L., and Gil-Chaviano M. (1993) Local synthesis of immunoglobulins in meningoencephalitis, inCNS Barriers and Modern CSF Diagnostics (Felgenhauer K., Holzgraefe M., and Prange H. W., eds.), pp. VCH, Weinheim, 396–399.

    Google Scholar 

  • Dorta-Contreras A. J., Reiber H., Álvarez-Cermeño J. C., and Escobar-Pérez X. (1995) Estudio neuroinmunológico de pacientes pediátricos con meningoencefalitis a echo 6.Revista CNIC 26, 13.

    Google Scholar 

  • Dorta-Contreras A. J., Interián-Morales M. T., Noris-García E., Mechulam-Cohen A., Muñoz-Cuellar L., Agüero-Valdés E., and Cepero-Rodríguez A. (1996) Inmunodeficiencia transitoria de IgG1 en el curso de una meningoencefalitis a Streptococcus preumoniae.Rev. Esp. Pediatr. 52, 463–466.

    Google Scholar 

  • Reiber H. and Lange P. (1991) Quantitative of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain.Clin. Chem. 37, 1153–1160.

    PubMed  CAS  Google Scholar 

  • Reiber H. (1994) The hyperbolic function: A mathematical solution of the protein flux/CSF flow model for blood-CSF barrier function.J. Neurol. Sci. 126, 243–245.

    Article  Google Scholar 

  • Reiber H. (1995) External quality assessment in clinical neurochemistry: Survey of analysis of cerebrospinal fluid (CSF) proteins based on CSF/Serum quotients.Clin. Chem. 41, 256–263.

    PubMed  CAS  Google Scholar 

  • Reiber H. (1996) Evaluation of blood-CSF barrier function and quantification of the humoral immune response within the CNS, inCerebrospinal Fluid Analysis in Multiple Sclerosis (Thompson E. J., Trojano M., and Livrea P., eds.), Springer Verlag, Milan, pp. 51–72.

    Google Scholar 

  • Reiber H. (1998) Cerebrospinal fluid-physiology analysis and interpretation of protein patterns for diagnosis of neurological diseases.Mult. Scler. 4, 99–107.

    PubMed  CAS  Google Scholar 

  • Reiber H. and Felgenhauer K. (1987) Protein transfer at the blood spinal cerebrospinal fluid and the quantitation of humoral immune response within the central nervous system.Clin. Chim. Acta 13, 319–328.

    Article  Google Scholar 

  • Sierra G. G., Campa C., Valcarcel N. W., García I. L., Sotolongo P. F., Izquierdo P. L., et al. (1991) Vaccine against group B Neisseria meningitidis: protection trial and mass vaccination results in Cuba.NIPH Ann. 14, 195–207.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hospital Pediátrico San Miguel, Apartado Postal 10049, CP 11000, Ciudad de La Habana, Cuba

    Alberto J. Dorta Contreras

Authors
  1. Alberto J. Dorta Contreras
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dorta Contreras, A.J. Intrathecal synthesis of immunoglobulins inNeisseria meningitidis and echovirus 6 meningoencephalitis. J Mol Neurosci 12, 81–87 (1999). https://doi.org/10.1007/BF02736922

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02736922

Index Entries

Search

Navigation