Abstract
This study investigated terminal dUTP nick-end labeling (TUNEL)-positive cells in the frontal, occipital, and hippocampal cortices of seven normal aging and four Alzheimer’s patients. Significant increase in TUNEL-positive cells was observed in the frontal and hippocampal cortices of Alzheimer’s patients when compared with controls. In the hippocampal cortex, only area CA4 demonstrated a significant increase of TUNEL-positive cells. Double staining of TUNEL-positive cells for glial fibrillary acidic protein revealed that <13% of the TUNEL-positive nuclei belonged to astrocytes. The results of this study illustrated a differential pattern of cortical degeneration between normal aging and Alzheimer patients.
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Li, W.P., Chan, W.Y., Lai, H.W.L. et al. Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and alzheimer patients. J Mol Neurosci 8, 75–82 (1997). https://doi.org/10.1007/BF02736774
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DOI: https://doi.org/10.1007/BF02736774