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Neonatal screening for Glucose-6-Phosphate dehydrogenase deficiency

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Abstract

Objective : This study was carried out to detect the incidence of erythrocytic Glucose-6-Phosphate dehydrogenase (G-6-PD) deficiency, to compare the incidence of hyperbilirubinernia in G-6-PD deficient neonates as compared to G-6-PD normal neonates and to asses the usefulness of neonatal screening for G-6-PD deficiency.Method : In a retrospective hospital based study 2,479 male and female neonates consecutively born at Indraprastha Apollo hospital between July 1998 to June 2003 who were screened for G-6-PD levels were evaluated for the incidence of G-6-PD deficiency.Results : Incidence of G-6-PD deficiency was found to be 2.0%. Incidence in males was 283% and femle was 1.05%. The incidence of hyperbilirubinemia was found to be 32% in G-6-PD deficient neonates which was significantly higher than the incidence of hyperbilirubinemia in neonates with normal G-6-PD, which was 12.3% (P<0.001).Conclusion : Our data suggests that neonatal screening for G-6-PD deficiency is a useful test for preventing and early treatment of complications associated with it.

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Authors and Affiliations

  1. Division of Neonatology, Apollo Center for Advanced Pediatrics, Indraprastha Apollo Hospital, New Delhi, India

    Mritunjay Pao, Anjali Kulkarni (Senior Consultant, Neonatology), Vidya Gupta, Sushma Kaul & Saroja Balan

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  1. Mritunjay Pao
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  2. Anjali Kulkarni
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  3. Vidya Gupta
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Correspondence to Anjali Kulkarni.

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Pao, M., Kulkarni, A., Gupta, V. et al. Neonatal screening for Glucose-6-Phosphate dehydrogenase deficiency. Indian J Pediatr 72, 835–837 (2005). https://doi.org/10.1007/BF02731109

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