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Lung surfactant and pulmonary toxicology

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Abstract

Pulmonary surfactant is essential for a proper functioning of the mammalian lung. It provides mechanical stability to the alveoli, prevents alveolar edema, and plays a role in the pulmonary defense system. Because of this vital role, alterations in the surfactant system may account for some of the observed toxic effects of environmental agents and drugs on the lung. In this review we will discuss the effects of several noxious agents such as oxidant gases, smoke, dusts, and herbicides on the quality and production of surfactant.

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  1. Laboratory of Veterinary Biochemistry, State University of Utrecht, Utrecht, The Netherlands

    Henk P. Haagsman & Lambert M. G. van Golde

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Haagsman, H.P., van Golde, L.M.G. Lung surfactant and pulmonary toxicology. Lung 163, 275–303 (1985). https://doi.org/10.1007/BF02713827

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