References
Bond J, Roberts E, Mochida G H, Hampshire D J, Scott S, Askham J M, Springell K, Mahadevan M, Crow Y J, Markham A F, Walsh C A and Woods C G 2002 ASPM is a major determinant of cerebral cortical size;Nat. Genet. 32 316–320
Huyton T, Bates P A, Zhang X, Stenberg M J and Freemont P S 2000 The BRCA1 C-terminal domain: structure and function;Mutat. Res. 460 319–332
Jackson A P, Eastwood H, Bell S M, Adu J, Toomes C, Carr I M, Roberts E, Hampshire D J, Crow Y J, Mighell A J, Karbani G, Jafri H, Rashid Y, Mueller R F, Markham A F and Woods C G 2002 Identification of microcephalin, a protein implicated in determining the size of the human brain;Am. J. Hum. Genet. 71 136–142
Jackson A P, McHale D P, Campbell D A, Jafri H, Rashid Y, Mannan J, Karbani G, Corry P, Levene M L, Mueller R F, Markham A F, Lench N J and Woods C G 1998 Primary autosomal microcephaly (MCPH1) maps to chromosome 8p22-pter;Am. J. Hum. Genet. 63 541–546
Jamieson C R, Fryns J P, Jacobs J, Matthijs G and Abramowicz M J 2000 Primary autosomal recessive microcephaly: MCPH5 maps to 1q25-1q32;Am. J. Hum. Genet. 67 1575–1577
Jamieson C R, Govaerts C and Abramowicz M J 1999 Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15;Am. J. Hum Genet. 65 1465–1469
Mochida G H and Walsh C A 2001 Molecular genetics of human microcephaly;Curr. Opin. Neurol. 14 151–156
Moynihan L, Jackson A P, Roberts E, Karbani G, Lewis I, Corry P, Turner G, Mueller R F, Lench N J and Woods C G 2000 A third locus for primary autosomal recessive microcephaly maps to chromosome 9q34;Am. J. Hum. Genet. 66 724–777
Pattison L, Crow Y J, Deeble V J, Jackson A P, Jafri H, Rashid Y, Roberts E and Woods C G 2000 A fifth locus for primary autosomal recessive microcephaly maps to chromosome 1q31;Am. J. Hum. Genet. 67 1578–1580
Roberts E, Hampshire D J, Pattison L, Springell K, Jafri H, Corry P, Mannon J, Rashid Y, Crow Y, Bond J and Woods C G 2002 Autosomal recessive primary microcephaly: an analysis of locus heterogeneity and phenotypic variation;J. Med. Genet. 39 718–721
Roberts E, Jackson A P, Carradice A C, Deeble V J, Mannan J, Rashid Y, McHae D P, Markham A F, Lench N J and Woods C G 1999 The second locus for autosomal recessive primary microcephaly (MCPH2) maps to chromosome 19ql3-1-13-2;Eur. J. Hum. Genet. 7 815–820
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kumar, A., Markandaya, M. & Girimaji, S.C. Primary microcephaly:microcephalin andASPM determine the size of the human brain. J Biosci 27, 629–632 (2002). https://doi.org/10.1007/BF02708369
Issue Date:
DOI: https://doi.org/10.1007/BF02708369