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Antifertility effect of tamoxifen as tested in the female bonnet monkey (Macaca radiata)

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Abstract

The administration of a potent antiestrogen, tamoxifen at a dose of 3 mg/kg body weight/day orally post-coitally to cycling mated bonnet monkeys(Macaca radiata) from days 18–30 of cycle resulted in inhibition of establishment of pregnancy in 9 out of 10 monkeys. Tamoxifen effect was not due to interference with luteal function. The effect was specific to tamoxifen as exogenously administered progesterone could not reverse it. In addition to suggesting a role for estrogen in maintenance of early pregnancy in the primate the present study could be a prelude to the development of an effective post-ovulatory approach for regulation of fertility in the human female

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Abbreviations

MPA:

Medroxyprogesterone acetate

mCG:

monkey chorionic gonadotropin

References

  • Bosu, W. T. K. and Johansson, E. D. B. (1975)Acta Endocrinol. (Copenhagen),79, 598.

    Article  CAS  Google Scholar 

  • Furr, B. J. A., Paterson, J. S., Richardson, D. K., Slater, S. R. and Wakeling, A. E. (1979) Tamoxifen; inPharmacological and Biochemical Properties of Drug Substances, (ed. M. E. Goldberg) (Washington: American Pharmaceutical Association) Vol. 2, p. 355.

    Google Scholar 

  • Meyer, R. K., Wolf, R. C. and Arslan, M. (1969) inRecent Advances in Primatology, (ed. A. Hoffer) (Basel: Karger) Vol. 2, p. 30.

    Google Scholar 

  • Morris, J. M., Van Wagenen, G., McCann, T. and Jacob, D. (1967)Fertil. Steril.,18, 18.

    Article  CAS  Google Scholar 

  • Moudgal, N. R., Mukku, V. R., Prahalada, S., Murthy, G. S. R. C. and Li, C. H. (1978)Fertil. Steril.,30, 223.

    Article  CAS  Google Scholar 

  • Prasad, M. R. N. (1985)J. Biosci.,7,1.

    Article  Google Scholar 

  • Rao, A. J., Kotagi, S. G. and Moudgal, N. R. (1984)J. Reprod. Fertil.,70,449.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Center for Advanced Research in Reproductive Biology, Indian Institute of Science, 560 012, Bangalore, India

    N. Ravindranath & N. R. Moudgal

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  1. N. Ravindranath
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  2. N. R. Moudgal
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Ravindranath, N., Moudgal, N.R. Antifertility effect of tamoxifen as tested in the female bonnet monkey (Macaca radiata). J. Biosci. 10, 167–170 (1986). https://doi.org/10.1007/BF02702852

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  • DOI: https://doi.org/10.1007/BF02702852

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