Skip to main content
SpringerLink
Log in

Effect of peptide Pro-Gly-Pro on stress-induced behavioral changes in rats

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Tripeptide PGP in a dose of 1 mg/kg had a correcting effect on behavioral disorders in rats induced by stress exposure (forced swimming). PGP prevented the increase in anxiety and decrease in orientation and exploratory activity. Our results suggest that the effect of this peptide is realized via central nervous structures involved in organism’s response to stress factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. M. A. Abramova, G. E. Samonina, and I. P. Ashmarin,Neirokhimiya,13, No. 3, 209–214 (1996).

    Google Scholar 

  2. I. P. Ashmarin, E. P. Karazeeva, L. A. Lyapina, and G. E. Samonina,Biokhimiya,63, No. 2, 119–124 (1998).

    CAS  Google Scholar 

  3. I. P. Ashmarin, G. E. Samonina, N. Ya. Zheleznyak, and Z. V. Bakaeva,Dokl. Akad. Nauk SSSR,368, No. 5, 709–710 (1999).

    CAS  Google Scholar 

  4. B. V. Vas’kovskii, Yu. A. Zolotarev, S. E. Zhuikova, et al., Vopr. Med. Biol. Farm. Khimii, No. 3, 45–57 (2003).

  5. S. E. Zhuikova, Z. V. Bakaeva, and G. E. Samonina, Vestn Mosk. Gos. Univ. Ser. 16. Biol., No. 2, 20–22 (2002).

  6. A. A. Kamenskii and K. V. Savel’eva, Nitric Oxide and Behavior [in Russian], Moscow (2002).

  7. N. G. Levitskaya, N. V. Latysheva, N. A. Andreeva, and A. A. Kamenskii, Vestn. Mosk. Gos. Univ. Ser. 16. Biol., No. 2, 17–22 (2002).

  8. E. A. Smirnova, L. Ts. Sanzhieva, B. A. Umarova, and T. V. Lelekova,Byull. Eksp. Biol. Med.,136, No. 11, 497–499 (2003).

    Google Scholar 

  9. B. A. Umarova, G. N. Kopylova, E. A. Smirnova,et al., |Ibid.Byull. Eksp. Biol. Med.,136, No. 10, 371–373 (2003).

    Google Scholar 

  10. S. Chaki, S. Hirota, T. Funakoshi,et al., J. Pharmacol. Exp. Ther.,304, No. 2, 818–827 (2003).

    Article  PubMed  CAS  Google Scholar 

  11. S. Mercier, A. Buguet, R. Cespuglio,et al., Behav. Brain Res.,139, Nos. 1–2, 167–175 (2003).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, USSR

    G. N. Kopylova, S. E. Badmaeva, N. G. Levitskaya, G. E. Samonina, B. A. Umarova & A. A. Guseva

Authors
  1. G. N. Kopylova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. E. Badmaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. G. Levitskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. E. Samonina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. A. Umarova
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. A. Guseva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. E. Samonina.

Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 7, pp. 9–11, July, 2004

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kopylova, G.N., Badmaeva, S.E., Levitskaya, N.G. et al. Effect of peptide Pro-Gly-Pro on stress-induced behavioral changes in rats. Bull Exp Biol Med 138, 5–7 (2004). https://doi.org/10.1007/BF02694459

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02694459

Key Words

Search

Navigation