Summary
An oral glucose load or a single i.m. insulin injection given to normal human subjects was followed within 1 h by a fall in total serum apolipoprotein B concentration. Although both procedures caused a concomitant drop in serum albumin concentration, the apolipoprotein-B/albumin ratio fell significantly, indicating that the drop in serum apolipoprotein B concentration cannot be explained by hemodilution.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chait A., Bierman E. L., Albers J. J.: Regulatory role of insulin in the degradation of LDL by cultured human skin fibroblasts — Biochim. biophys. Acta (Amst.)529, 292, 1978.
Chait A., Edwin L., Bierman E. L., Albers J. J.: Regulatory role of triiodothyronine in the degradation of LDL by cultured human skin fibroblasts — J. clin. Endocrinol.48, 887, 1979.
Doumas B. T., Watson W. A., Biggs H. G.: Albumin standards and measurement of serum albumin with bromocresol green — Clin. chim. Acta31, 87, 1971.
Frier B. M., Corral R. J. M., Davidson N. Mc. D., Webber R. G., Dewar A., French E. B.: Peripheral hypoglycaemia in man — Europ. J. clin. Invest.13, 33, 1983.
Gundersen H. J. G., Christensen N. J.: Intravenous insulin causing loss of intravascular water and albumin and increased adrenergic nervous activity in diabetics — Diabetes26, 551, 1977.
Havel R. J., Eder H. A., Bracdon J. H.: The distribution and the composition of ultracentrifugally separated lipoproteins in human serum — J. clin. Invest.34, 1345, 1955.
Herbert V., Lau K., Gottlieb W., Bleicher S. J.: Coated charcoal immunoassay of insulin — J. clin. Endocrinol.25, 1375, 1965.
Hyelm M.: Enzymatic determination of exoses in blood and urine — Scand. J. Lab. Invest.18 (Suppl. 192), 85, 1966.
Klose S., Hagen A., Grief H.: Méthode de dosage colorimetrique du cholestérol par voie entièrement enzymatique adaptée à tous les types d’autoanalyseurs. In: Organisation des Laboratoires-Biologie Prospective, III Colloque de Pont-à-Mousson. Expansion Sci. Franç. Éd., Paris, 1975; p. 505.
Mondola P., Reichl D.: Apoprotein B of lipoprotein (a) of human plasma — Biochem. J.208, 393, 1982.
Nestel P. J., Reardon M., Fidge N. H.: Sucrose-induced changes in VLDL and LDL-B apoprotein removal rates — Metabolism28, 531, 1979.
Thompson G. R., Soutar A. K., Spengel F. A., Jadhav A., Gavigan S. J., Myant N. B.: Defects of receptor-mediated LDL catabolism in homozygous familial hypercholesterolemia and hypothyroidismin vivo — Proc. nat. Acad. Sci. (Wash.)78, 2591, 1831.
Wahlefeld A. N.: Triglycerides determination after enzymatic hydrolysis. In:Bergmeyer H. U. (Ed.): Methods of enzymatic analysis. Academic Press, New York 1974; p. 1978.
WHO Expert Committee on Diabetes Mellitus. Second Report, Technical Report Series 646 WHO, Geneva, 1980; p. 9.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mondola, P., Patti, L., Santangelo, F. et al. Changes in serum apolipoprotein B concentration after oral glucose or intramuscular insulin. Acta diabet. lat 21, 235–240 (1984). https://doi.org/10.1007/BF02642896
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02642896