Abstract
The temporal bones from fetuses with known autosomal trisomy syndromes were examined histopathologically after spontaneous or induced abortions. Fetal ages dated from the 17th to the 24th week of pregnancy. In all, 17 temporal bones from nine fetuses were studied and included seven cases of Down's syndrome and two of Edwards' syndrome. Temporal bones from fetuses with Down's syndrome had more abnormalities of the external and middle ears than of the inner ear. The bones from the fetuses with Edwards' syndrome showed abnormalities of the external or middle ear and retarded development of the inner ear (failed ossification of the otic capsule and unformed organ of Corti).
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References
Fritsch MH, Sommer A (1990) Handbook of congenital and early onset hearing loss. Igaku-Shoin, New York, pp 122–131
Harada T, Sando I (1981) Temporal bone histopathologic findings in Down's syndrome. Arch Otolaryngol 107:96–103
Igarashi M, Takahashi M, et al (1977) Inner ear morphology in Down's syndrome. Acta Otolaryngol (Stockh) 83:175–181
Kahn ZM, Adour KK (1978) Histologic findings in the temporal bone in trisomy D (D/D translocation). Arch Otolaryngol 104:22–25
Kos AO, Schuknecht HF, et al (1966) Temporal bone studies in 13–15 and 18 trisomy syndromes. Arch Otolaryngol 83:439–445
Lejeune J, Gauthier M, et al (1959) Etude des chromosomes somatiques de neuf enfants monogoliens. C R Acad Sci 248:1721–1722
Maniglia AJ, Wolff D, et al (1970) Congenital deafness in 13–15 trisomy syndrome. Arch Otolaryngol 92:181–188
Patau K, Smith DW, et al (1960) Multiple congenital anomaly caused by an extra autosome. Lancet I:790–793
Roizen NJ (1993) Hearing loss in children with Down syndrome. J Pediatr 123:9–12
Sando I, Bergstrom V, et al (1970) Temporal bone findings in trisomy 18 syndrome. Arch Otolaryngol 91:552–559
Schuknecht HF (1980) Mondini dysplasia. A clinical and pathological study. Ann Otol Rhinol Laryngol 65 [Suppl]:1–23
Zizka J (1994) Diagnosis of syndromes and malformations (in Czech). Galén, Prague, pp 262–263, 269–270
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Chrobok, V., Šimáková, E. Temporal bone findings in trisomy 18 and 21 syndromes. Eur Arch Otorhinolaryngol 254, 15–18 (1997). https://doi.org/10.1007/BF02630750
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DOI: https://doi.org/10.1007/BF02630750