Abstract
Selective intraarterial neoadjuvant chemotherapy of carcinoma in the region of the lingual artery was performed in 23 patients (bilaterally in 4 patients). The superficial temporal artery (STA) was surgically exposed and a preshaped infusion catheter was inserted. The catheter tip was maneuvered through the STA into the lingual artery under fluoroscopic guidance. Two combinations of cytostatic agents were then continually infused through the catheter for 5–9 days. Treatment response was observed in 16 patients, 9 of whom showed a complete response. The combination of cisplatin and 5-fluorouracil was found most effective. The catheter became dislocated six times among 27 catheterizations and in each instance the position could be corrected. No major complications were encountered. We conclude that selective infusion technique is safer than previously reported semiselective infusions techniques.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ramsden CH, Duff JK (1963) Continuous arterial infusion of head and neck tumors. Cancer 16:133–135
Lee YY, Dimery TW, Van Tassel P, De Pena C, Blacklock JB, Goepfert H (1989) Superselective intra-arterial chemotherapy of advanced paranasal sinus tumors. Arch Otolaryngol Head Neck Surg 115:503–511
Tournade A, Cortheoux P, Tajahmady T, Nagy I, Theron J, Braun JP, Valdazo A, Gerber JC (1987) La chimio-embolisation des tumeurs malignes de la face. J Neuroradiol 14:125–140
Baker SR, Forastiere AA, Wheeler R, Medvec BR (1987) Intra-arterial chemotherapy for head and neck cancer. Arch Otolaryngol Head Neck Surg 113:1183–1190
Laszig R, Lütgebrune T (1989) Katheterimplantation zur intraarteriellen Chemotherapie maligner Tumoren im Kopf-Halsbereich. HNO 37:140–143
Mees K, Lauterjung L, Kastenbauer E, Riederer A (1987) Unsere Katheterführung zur intraarteriellen Chemotherapie bei Kopf- und Hals-Karzinomen. Laryng Rhinol Otol 66: 460–464
Wheeler RH, Baker SR (1984) Single-agent and combination-drug regional chemotherapy for head and neck cancer using an implantable infusion pump. Cancer 54:1504–1512
Bilder J (1988) Neo-adjuvant chemoinduction in oncotherapy of oral carcinomas. Cs. Stomat 88:275–279
Jacobs JR, Pajak TF, Kinzie J, Al-Sarraf M, Davis L, Hanks GA, Weigensberg I, Leibel S (1987) Induction chemotherapy in advanced head and neck cancer. Arch Otolaryngol Head Neck Surg 113:193–197
Cheung DK, Regan J, Savin M, Gibberman V, Woessner W (1988) A pilot study of intraarterial chemotherapy with cisplatin in locally advanced head and neck cancers. Cancer 61:903–908
Sulfaro S, Frustaci S, Volpe R, Barzan L, Comoretto R, Monfardini S, Carbone A (1989) A pathologic assessment of tumor residue and stromal changes after intraarterial chemotherapy for head and neck carcinomas. Cancer 64:994–1001
Jesse RH, Villarreal R, Letayf V, Rufino C, Hickey RC (1964) Intra-arterial infusion for head and neck cancer. Arch Surg 88:618–627
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Simunek, A., Krajina, A. & Hlava, A. Selective intraarterial chemotherapy of tumors in the lingual artery territory by a new approach. Cardiovasc Intervent Radiol 16, 392–395 (1993). https://doi.org/10.1007/BF02603148
Issue Date:
DOI: https://doi.org/10.1007/BF02603148