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Long-term control of hypertension and the predictive value of peripheral plasma renin activity after ablation of end stage kidneys with a new embolic agent

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Abstract

Embolization of end-stage kidneys using our own embolizing agent Vilanol (partially hydrolyzed polyvinyl acetate) was performed in 10 patients with hypertension refractory to conservative therapy. Native kidneys were embolized in 7 patients with chronic renal failure, nonfunctioning renal transplants in 2 patients, and a shrunken kidney in 1 patient. Five of the 10 patients had high (9.96–18.2 ng/ml/h) peripheral renin (PR) levels. The embolization was technically successful in 4 of these 5 patients and was immediately followed by a marked decrease in PR, and simultaneous improvement in blood pressure (BP). The other 5 patients had very low PR levels (0.07–0.65 ng/ml/h), and a reduction in BP was observed in 4 after embolization. One patient died following embolization from cardiac arrest due to hyperkalemia. Six patients (3 in each group) have been on follow-up for 2–5 years with sustained decrease in BP. We conclude that the new agent is effective for renal ablation and control of refractory hypertension.

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Authors and Affiliations

  1. Department of Radiology, Institute for Clinical and Experimental Medicine, Vídeňská 800, 140 00, Prague 4, Czech Republic

    Jan H. Peregrin & Vladimír Borůvka

  2. 1st Department of Medicine, Charles University School of Medicine, U nemocnice 2, 120 00, Prague 2, Czech Republic

    Jiří Žabka

  3. Department of Medicine III, Institute for Clinical and Experimental Medicine, Vídeňská 800, 140 00, Prague 4, Czech Republic

    Jarmila Stříbrná & Vojtěch Martínek

Authors
  1. Jan H. Peregrin
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  2. Jiří Žabka
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  3. Jarmila Stříbrná
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  4. Vladimír Borůvka
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  5. Vojtěch Martínek
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Peregrin, J.H., Žabka, J., Stříbrná, J. et al. Long-term control of hypertension and the predictive value of peripheral plasma renin activity after ablation of end stage kidneys with a new embolic agent. Cardiovasc Intervent Radiol 16, 355–360 (1993). https://doi.org/10.1007/BF02603140

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