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Experimental hyperthermia of nude mice controlled by microwave thermometry

Radiometerkontrollierte experimentelle Hyperthermie von Nacktmäusen

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  • Main Topics: Hyperthermia in Clinical Oncology
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Abstract

Pilot experiments, with a hyperthermia-system for the treatment of human tumors xenotransplanted into nude mice, are described. The tumors are heated by microwaves at 2,45 GHz. The treatment is controlled by non-invasive thermometry, the radiometry. Before in-vivo treatments could be started, the system had to be tested very carefully in a series of phantom experiments, in order to prove the reliability of the whole unit.

Zusammenfassung

In der vorliegenden Arbeit werden erste Messungen an einem Hyperthermiesystem beschrieben. Mit diesem System ist geplant, menschliche Tumore, die auf die Nacktmaus transplantiert sind, zu hyperthermieren. Die Tumoren werden mit Mikrowellen einer Frequenz von 2,45 GHz erwärmt. Die Regelung des Systems geschieht nichtinvasiv mit Hilfe der Mikrowellenthermometrie. Vor dem In-vivo-Einsatz wurden eine Reihe von Phantomexperimenten durchgeführt, die die Zuverlässigkeit des Hyperthermiesystems unter Beweis stellten.

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Bruggmoser, G., Hinkelbein, W., Saum, R. et al. Experimental hyperthermia of nude mice controlled by microwave thermometry. Acta Chir Austriaca 24, 199–200 (1992). https://doi.org/10.1007/BF02601740

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  • DOI: https://doi.org/10.1007/BF02601740

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