Summary
In the sera of humans and various animals there are two different non-specific inhibitors (α-and β-inhibitors) which may be specifically abolished by two substances (α-and β-“enzymes”) both present in filtrates ofV. cholerae. This neutralization is necessary for the rapid classifying of influenza virus strains with the aid of the haemagglutination inhibition test.
The egg line strains of the A- and A′-groups are only sensitive to β-inhibitor, while the mouse line strains of the same groups are only sensitive to the α-inhibitor. This does not apply to strains of the B group, where mouse as well as egg lines are sensitive to both inhibitors.
With the aid of isolated β-inhibitor (easily to be prepared from cattle serum), it is possible to decide in a quick manner whether or not a strain from the A- or A′-group has previously been adapted to the mouse.
Similar content being viewed by others
References
Ada, G. L. andFrench, E. L. 1950. Austr. J. Sc.13, 3, 82.
Burnet, F. M. 1948. Austr. J. Exp. Biol. Med. Sc.26, 71.
Burnet, F. M., Mc Crea, J. F. andStone, J. D. 1946. Brit. J. Exp. Path.27, 228.
Burnet, F. M., Mc Crea J. F. andAnderson, S. G. 1947. Nature160, 404.
Burnet, F. M. andStone, J. D. 1947. Austr. J. Exp. Biol. Med. Sc.25, 227.
Chu, C. M. 1951. J. Gen. Microbiol. (Suppl.)5, 739.
Francis, T. 1947. J. Exp. Med.85, 1.
Ginsberg, H. S. andHorsfall, F. L. 1949. J. Exp. Med.90, 393.
Gottschalk, A. andLind, P. E. 1949. Brit. J. Exp. Path.30, 85.
Isaacs, A. andBozzo, A. 1951. Brit. J. Exp. Path.32, 325.
Mc Crea, J. F. 1946. Austr. J. Exp. Biol. Med. Sc.24, 283.
Mulder, J., van der Veen, J., Brans, L. M. andEnserink, S. W. 1949. Antonie van Leeuwenhoek15, 162.
Mulder, J. andvan der Veen, J. 1948. Acta Brev. Neerl.16, 57.
Sampaio, A. A. C. 1952. Bull. W.H.O.6 4, 467.
Sampaio, A. A. C. andIsaacs, A. 1953. Brit. J. Exp. path.34, 2, 152.
Smith, W., Westwood, J. C. N. andBelyavin, G. 1951. Lancet2, 1189.
Stone, J. D. 1949. Austr. J. Exp. Biol. Med. Sc.27, 229.
van der Veen, J. andMulder, J. 1950. Monogr. Inst. Praev. Med., Leyden,9.
Author information
Authors and Affiliations
Additional information
With the technical assistance of Miss I.de Nooyer and with the financial support provided by the Institute for Preventive Medicine, Leyden; N.V. Philips Roxane, Weesp; the State Department of Science; the Jan Dekker Fund, and the Curacao Fund for Preventive Medicine.
Rights and permissions
About this article
Cite this article
Brans, L.M., Hertzberger, E., Binkhorst, J.L. et al. Studies on the elimination of non-specific inhibitors in sera against influenza viruses with the aid of filtrates ofVibrio cholerae . Antonie van Leeuwenhoek 19, 309–323 (1953). https://doi.org/10.1007/BF02594858
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02594858