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Heat flow in laser treatment by local hyperthermia

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Abstract

A mathematical model for laser treatment of tumours is proposed, and is based on a diffusion approximation to the distribution of laser energy in tissue. Spherically symmetrical solutions are possible, and they give some insight into the character of the solution. The full set of equations has been solved numerically for blood thrombus, and the solution is found to suggest a number of simplifications to the assumption, which may be useful in future theoretical work. Temperature profiles were obtained, together with predictions for the region treated. These are found to agree satisfactorily with the results of experiments on the livers of rats.

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References

  1. Cummins L, Nauenberg N. Thermal effects of laser radiation in biological tissue.Biophys J 1983,42:99–102

    Article  PubMed  CAS  Google Scholar 

  2. Welch AJ, Motamedi M. Interaction of laser light with biological tissue. In: Martellucci S, Chester AN (eds)Laser photobiology and photomedicine, New York: Plenum, 1985:29–53

    Google Scholar 

  3. Svaasand L. Thermal and optical dosimetry and photoradiation therapy of malignant tumors. In: Cubeddu R, Andreoni A (eds)Porphyrins in tumor phototherapy, New York: Plenum, 1984:261–79

    Google Scholar 

  4. Matthewson K, Coleridge-Smith P, O'Sullivan JP et al. Biological effects of intra-hepatic Nd-YAG laser photocoagulation in rats.Gastroenterology, in press

  5. Barnes FS. Applications of lasers to biology and medicine.Proc Inst Elec Electron Eng 1975,63:1269–78

    CAS  Google Scholar 

  6. van Gemert MJC, de Klein WJA, Hulsberger-Henning JP. Temperature behaviour of a model port-wine stain during argon-laser coagulation.Phys Med Biol 1982,27:1089–1104

    Article  PubMed  Google Scholar 

  7. Welch AJ. Thermal response of laser-irradiated biological tissue.Inst Elec Electron Engl J Quant Electron 1984,QE20:1471–80

    Google Scholar 

  8. Svaasand LO, Doiron DR, Dougherty TJ. Temperature rise during photoradiation therapy of malignant tumours.Med Phys 1983,1:10

    Article  Google Scholar 

  9. Doiron DR, Svaasand LO, Profio AE. Lasers in medicine and surgery,SPIE J 1982,357:48–52

    CAS  Google Scholar 

  10. Ishimaru A.Wave propagation and scattering in random media, Vol. 1 New York: Academic Press, 1978: Chap 10

    Google Scholar 

  11. Carslaw HS, Jaeger JC:Conduction of heat in solids, 2nd edn, Oxford: Clarendon Press, 1959 Chap 1

    Google Scholar 

  12. Patterson J, Strang R. The role of blood flow in hyperthermia.Int J Radiat Oncol Biol Phys 1979,5:235–41

    PubMed  CAS  Google Scholar 

  13. Plengvanit U, Suwanik R, Chearanai O et al. Regional hepatic blood flow studied by intrahepatic injection of133Xenon.Aust NZ J Med 1972,2:44–8

    CAS  Google Scholar 

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Dowden, J.M., Davis, M., Kapadia, P. et al. Heat flow in laser treatment by local hyperthermia. Laser Med Sci 2, 211–221 (1987). https://doi.org/10.1007/BF02594161

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  • DOI: https://doi.org/10.1007/BF02594161

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