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Red cell 2,3-DPG levels in diabetic vasculopathy

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Summary

RBC 2,3-DPG resulted statistically increased versus normal subjects in 22 insulin-dependent diabetics affected by arterial vasculopathy and in 19 vasculopathic non-diabetic patients. RBC 2,3-DPG, on the other hand, did not differ from the normal mean in 16 insulin-dependent diabetics without vascular involvement. The increase of RBC 2,3-DPG represents principally a consequence of the vasculopathy.

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References

  1. Alberti K. G. M. M., Emerson P. M., Darley J. H., Hockaday T. D. R.: Red cell 2,3-diphosphoglycerate and diabetes — Lancet1, 843, 1972.

    Article  PubMed  CAS  Google Scholar 

  2. Alberti K. G. M. M., Emerson P. M., Darley J. H., Hockaday T. D. R.: 2,3-diphosphoglycerate and tissue oxygenation in uncontrolled diabetes mellitus — Lancet2, 391, 1972.

    Article  PubMed  CAS  Google Scholar 

  3. Andersen H., Ditzel J.: Importance of plasma inorganic phosphate in the treatment of diabetic ketoacidosis — Diabetes22 (Suppl. 1), 293, 1973.

    Google Scholar 

  4. Benesch R., Benesch R. E.: The effect of organic phosphates from human erythrocytes on the allosteric properties of hemoglobin — Biochem. biophys. Res. Commun.26, 162, 1967.

    Article  PubMed  CAS  Google Scholar 

  5. Chanutin A., Curnis R. R.: Effect of organic and inorganic phosphates on oxygen equilibrium of human erythrocytes — Arch. Biochem.121, 96, 1967.

    Article  PubMed  CAS  Google Scholar 

  6. Ditzel J.: Impaired oxygen release caused by alterations of the metabolism in the erythrocytes in diabetes — Lancet1, 721, 1972.

    Article  PubMed  CAS  Google Scholar 

  7. Ditzel J.: Adaptive changes to tissue hypoxia in ambulatory juvenile diabetics — Diabetes22 (Suppl. 1), 317, 1973.

    Google Scholar 

  8. Ditzel J., Andersen H., Daugaard Peters N.: Increased haemoglobin A1c and 2,3-diphosphoglycerate in diabetes and their effects on red-cell oxygen-releasing capacity — Lancet2, 1034, 1973.

    Article  PubMed  CAS  Google Scholar 

  9. Ditzel J., Daugaard Peters N., Andersen H.: Oxygen affinity of haemoglobin and red cell-2,3-DPG in childhood diabetes — Diabetologia10, 363, 1974.

    Google Scholar 

  10. Ditzel J., Jaeger P., Standl E.: Haemoglobin A1c, red cell 2,3-diphosphoglycerate and haemoglobin-oxygen affinity before and after insulin in newly diagnosed diabetics — Diabetologia13, 390, 1977.

    Google Scholar 

  11. Hockaday T. D. R., Alberti K. G. M. M.: Oxygen delivery to the tissue — Clin. Endocr. Metab.1, 768, 1972.

    Google Scholar 

  12. Kanter Y., Bessman S., Bessman A. N.: Red cell 2,3-diphosphoglycerate levels among diabetic patients with and without vascular complications — Diabetes24, 724, 1975.

    Article  PubMed  CAS  Google Scholar 

  13. Kanter Y., Gerson J. R., Bessman A. N.: 2,3-Diphosphoglycerate, nucleotide phosphate and organic and inorganic phosphate levels during the early phases of diabetic ketoacidosis — Diabetes26, 429, 1977.

    Article  PubMed  CAS  Google Scholar 

  14. Lowry O. H., Passonneau J. V., Hasselberger F. X., Schulz D. W.: Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain — J. biol. Chem.239, 18, 1964.

    PubMed  CAS  Google Scholar 

  15. Nevis M. A.: Oxyhemoglobin equilibrium in ischemic heart disease — J. Amer. med. Ass.229, 804, 1974.

    Article  Google Scholar 

  16. Oski F. A., Gottlieb A. J., Delivoira-Papadopoulos M., Miller W. W.: Red cell diphosphoglycerate levels in subjects with chronic hypoxemia — New Engl. J. Med.280, 1165, 1969.

    Article  PubMed  CAS  Google Scholar 

  17. Rorth M., Parving H. H., Munkgaard S.: Red cell oxygen affinity and 2,3-diphosphoglycerate in diabetes — Lancet1, 1179, 1972.

    Article  PubMed  CAS  Google Scholar 

  18. Torrance J., Jacobs P., Restrepo A., Eschbach J., Lenfant C. A.: Intraerythrocytic adaptation to anemia — New Engl. J. Med.283, 165, 1970.

    Article  PubMed  CAS  Google Scholar 

  19. Valeri C. R., Fortier N. L.: Red cell 2,3-diphosphoglycerate and creatinine levels in patients with red cell mass deficits or with cardiopulmonary insufficiency — New Engl. J. Med.281, 1452, 1969.

    Article  PubMed  CAS  Google Scholar 

  20. Woodson R. D., Torrance J. D., Shappell S. D., Lenfant C.: The effect of cardiac disease on hemoglobin-oxygen binding — J. clin. Invest.49, 1349, 1970.

    Article  PubMed  CAS  Google Scholar 

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Puxeddu, A., Brunetti, P., Calabrese, G. et al. Red cell 2,3-DPG levels in diabetic vasculopathy. Acta diabet. lat 16, 311–315 (1979). https://doi.org/10.1007/BF02587652

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  • DOI: https://doi.org/10.1007/BF02587652

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