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Effect of age on the binding of lectin125I-PHA-B to pancreatic islets of ratin vitro and stimulation of some cellular events

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Summary

Agaricus bisporus lectin (PHA-B) stimulates insulin releasein vitro. The stimulation is associated with increased conversion of proinsulin to insulin in the isolated islets of Langerhans of rats. Both these functions are directly proportional to the binding of I125 PHA-B, which is more marked in the islets from younger rats. The lectin binding to islets is not affected by glucose concentration in the medium.

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C.D.R.I. Communication No 4334.

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Khalid, P., Ahmad, F., Khan, M.M. et al. Effect of age on the binding of lectin125I-PHA-B to pancreatic islets of ratin vitro and stimulation of some cellular events. Acta diabet. lat 26, 171–180 (1989). https://doi.org/10.1007/BF02581369

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  • DOI: https://doi.org/10.1007/BF02581369

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