Abstract
Transcatheter arterial chemoembolization using a suspension of anticancer drug in iodized oil combined with Gelfoam embolization was performed in 85 patients with advanced primary hepatic carcinoma. Long-term retention of iodized oil in the tumor was observed in 90% of the cases, and changes in tumor size were observable by abdominal X-ray film on follow-up studies. There was a decrease of tumor size in all cases and the overall 1-year survival rate was 43%. In tumors whose diameter was less than 20 cm and in patients without portal vein thrombosis the survival rate was nearly 60%. Combined treatment with anticancer drug in iodized oil and Gelfoam embolization of the proper hepatic artery was superior to use of the suspension alone. There was also better detection of small cancer nodules by the suspension as compared to conventional angiography.
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References
Chuang VP, Wallace S (1981) Hepatic artery embolization in the treatment of hepatic neoplasms. Radiology 140:51–58
Charnsangavej C, Chuang VP, Wallace S, Soo CS, Bowers T (1983) Transcatheter management of primary carcinoma of the liver. Radiology 147:51–55
Yamada R, Sato M, Kawabata M, Nakatsuka H, Nakamura K, takashima S (1984) Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 148:397–401
Guo J, Huang Z, Liu P, Hu D (1987) Intraarterielle Chemotherapie und Embolisierung der Arteria hepatica bei primären Lebercarcinomen. Röntgenpraxis 40:211–214
Ohishi H, Uchida H, Yoshimura H, Ohue S, Ueda J, Katsuragi M, Matsuo N, Hosohi Y (1985) Hepatocellular carcinoma detected by iodized oil, use of anticancer agents. Radiology 154:25–29
Nakakuma K, Tashiro S, Uemura K, Konno T, Tanaka M, Yokoyama I (1979) An attempt at increasing effects of hepatic artery ligation for advanced hepatoma (in Japanese), Jap-Deutsche Med Berichte 24:675–682
Nakakuma K, Tashiro S, Hiraoka T, Uemura K, Konno T, Miyauchi Y, Yokoyama I (1983) Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding heaptic artery for liver cancer. Cancer 52:2193–2200
Iwai K, Maeda H, Konno T (1984) Use of oily contrast medium for selective drug targeting to tumor: Enhanced therapeutic effect and X-ray image. Cancer Res 44:2115–2121
Konno T, Maeda H, Iwai K, Tashiro S, Morinaga T, Mochinaga M, Hiraoka T, Yokoyama I (1983) Effect of arterial administration of high molecular-weight anticancer agent SMANGS with lipid lymphographic agent on hepatoma: A preliminary report. Eur J Cancer Clin Oncol 19:1035–1065
Kobayashi H, Hidaka H, Kajiya Y, Tanoue H, Ikeda K, Nakajo M, Shinohara S (1986) Treatment of hepatocellular carcinoma by transarterial injection of anticancer agents in iodized oil suspension or radioactive iodized oil solution. Acta Radiol [Diagn] (Stockh) 27:139–147.
Schijo Y, Inoue Y (1985) Embolisierung der Arteria hepatica bei primären hepatozellulären Karzinomen. Fortschr Röntgenstr 143:63–68
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Guo, J., Yen, D., Huang, Z. et al. Transcatheter arterial chemoembolization with anticancer drug in iodized oil for primary hepatic carcinoma. Cardiovasc Intervent Radiol 12, 181–187 (1989). https://doi.org/10.1007/BF02577150
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DOI: https://doi.org/10.1007/BF02577150