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Prognostic impact of lymphatic and/or blood vessel invasion in patients with node-negative advanced gastric cancer

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Abstract

Background

Heterogeneous survival rates in patients with similar clinicopathologic characteristics or molecular prognostic markers have been noted. This study was conducted to evaluate the prognostic effect of lymphatic and/or blood vessel invasion (LBVI), identified by routine hematoxylin and eosin staining, on the outcome of patients with node-negative advanced gastric cancer.

Methods

A total of 280 patients who underwent curative gastrectomy for advanced gastric cancer without lymph node metastasis were retrospectively reviewed. Univariate and multivariate analyses of the clinicopathological features, recurrences, and prognoses of patients with and without LBVI were performed.

Results

Lymphatic vessel invasion (LVI) was noted in 20.0%, blood vessel invasion (BVI) in 5.4%, and either LVI or BVI in 22.5%. None of the clinicopathologic features was related to LBVI. Patients with LBVI had a recurrence rate of 26.8%, whereas patients without LBVI had a recurrence rate of 13.5% (P=.018). The 5-year survival rates were 82.4% for patients without LBVI and 67.1% for patients with LBVI (P=.0222). LBVI was shown to be an independent risk factor for recurrence (relative risk, 2.30; 95% confidence interval, 1.06–4.99) and poor prognosis (relative risk, 1.88; 95% confidence interval, 1.07–3.29).

Conclusions

LBVI is an adverse prognostic indicator and the presence of LBVI seems to provide useful information for the prognosis and clinical management of patients with node-negative advanced gastric carcinoma.

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References

  1. Yoo CH, Noh SH, Shin DW, Choi SH, Min JS. Recurrence following curative resection for gastric carcinoma.Br J Surg 2000;87:236–42.

    Article  PubMed  CAS  Google Scholar 

  2. Park CH, Byun JY, Kim BK, Kim IC. Recurrent gastric cancer after curative surgery.J Korean Cancer Assoc 1998;30:488–96.

    Google Scholar 

  3. Becker KF, Keller G, Hoefler H. The use of molecular biology in diagnosis and prognosis of gastric cancer.Surg Oncol 2000;9:5–11.

    Article  PubMed  CAS  Google Scholar 

  4. Siewert JR, Böttcher K, Stein HJ, Roder JD. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study.Ann Surg 1998;228:449–61.

    Article  PubMed  CAS  Google Scholar 

  5. Kim JP. Surgical results in gastric cancer.Semin Surg Oncol 1999;17:132–8.

    Article  PubMed  CAS  Google Scholar 

  6. Roder JD, Böttcher K, Siewert JR, Busch R, Hermanek P, Meyer HJ. Prognostic factors in gastric carcinoma. Results of the German Gastric Carcinoma Study 1992.Cancer 1993;72:2089–97.

    Article  PubMed  CAS  Google Scholar 

  7. Maruyama K. The most important prognostic factors for gastric cancer patients. A study using univariate and multivariate analysis.Scand J Gastroenterol Suppl 1987;22:63–8.

    Google Scholar 

  8. Minsky BD, Mies C, Rich TA, Recht A, Chaffey JT. Potentially curative surgery of colon cancer: the influence of blood vessel invasion.J Clin Oncol 1988;6:119–27.

    PubMed  CAS  Google Scholar 

  9. Brechot JM, Chevret S, Charpentier MC, et al. Blood vessel and lymphatic vessel invasion in resected nonsmall cell lung carcinoma. Correlation with TNM stage and disease free and overall survival.Cancer 1966;78:2111–8.

    Article  Google Scholar 

  10. Lauria R, Perrone F, Carlomagno C, et al. The prognostic value of lymphatic and blood vessel invasion in operable breast cancer.Cancer 1995;76:1772–8.

    Article  PubMed  CAS  Google Scholar 

  11. Brucher BL, Stein HJ, Werner M, Siewert JR. Lymphatic vessel invasion is an independent prognostic factor in patients with a primary resected tumor with esophageal squamous cell carcinoma.Cancer 2001:92:2228–33.

    Article  PubMed  CAS  Google Scholar 

  12. Gabbert HE, Meier S, Gerharz CD, Hommel G. Incidence and prognostic significance of vascular invasion in 529 gastric-cancer patients.Int J Cancer 1991;49:203–7.

    Article  PubMed  CAS  Google Scholar 

  13. Setala LP, Kosma VM, Marin S, et al. Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration.Br J Cancer 1996;74:766–72.

    PubMed  CAS  Google Scholar 

  14. Maehara Y, Oshiro T, Baba H, Ohno S, Kohnoe S, Sugimachi K. Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer.Surgery 1995;117: 380–5.

    Article  PubMed  CAS  Google Scholar 

  15. Sobin LH, Wittekind C.International Union Against Cancer (UICC). TNM Classification of Malignant Tumours. 5th ed. New York: Wiley-Liss, 1997:59–62.

    Google Scholar 

  16. Nishi M, Omori Y, Miwa K.Japanese Research Society for Gastric Cancer (JRSGC). Japanese Classification of Gastric Carcinoma. Tokyo: Kanehara, 1995:6–15.

    Google Scholar 

  17. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations.J Am Stat Assoc 1958;53:457–81.

    Article  Google Scholar 

  18. Cox DR. Regression models and life tables.J R Stat Soc 1972;34: 187–220.

    Google Scholar 

  19. Noguchi Y. Blood vessel invasion in gastric carcinoma.Surgery 1990;107:140–8.

    PubMed  CAS  Google Scholar 

  20. Inada K, Shimokawa K, Ikeda T, Ozeki Y. The clinical significance of venous invasion in cancer of the stomach.Jpn J Surg 1990;20:545–52.

    Article  PubMed  CAS  Google Scholar 

  21. Sugarbaker EV. Patterns of metastasis in human malignancies.Cancer Biol Rev 1981;2:235–78.

    Google Scholar 

  22. Adachi Y, Mori M, Maehara Y, Kitano S, Sugimachi K. Prognostic factors of node-negative gastric carcinoma: univariate and multivariate analyses.J Am Coll Surg 1997;184:373–7.

    PubMed  CAS  Google Scholar 

  23. Harrison LE, Choe JK, Goldstein M, Meridian A, Kim SH, Clarke K. Prognostic significance of immunohistochemical micrometastases in node negative gastric cancer patients.J Surg Oncol 2000; 73:153–7.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea

    Woo Jin Hyung MD, Jun Ho Lee MD & Sung Hoon Noh MD

  2. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea

    Jun Ho Lee MD & Sung Hoon Noh MD

  3. Department of Surgery, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, Seoul, Korea

    Woo Jin Hyung MD, Jun Ho Lee MD, Seung Ho Choi MD, Jin Sik Min MD & Sung Hoon Noh MD

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  1. Woo Jin Hyung MD
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  2. Jun Ho Lee MD
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  3. Seung Ho Choi MD
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  4. Jin Sik Min MD
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  5. Sung Hoon Noh MD
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Correspondence to Sung Hoon Noh MD.

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Hyung, W.J., Lee, J.H., Choi, S.H. et al. Prognostic impact of lymphatic and/or blood vessel invasion in patients with node-negative advanced gastric cancer. Annals of Surgical Oncology 9, 562–567 (2002). https://doi.org/10.1007/BF02573892

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  • DOI: https://doi.org/10.1007/BF02573892

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