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Malondialdehyde serum concentration in type 1 diabetic with and without retinopaty

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Abstract

Lipid peroxides are thought to be formed by free radicals and have been implicated in the pathogenesis of diabetes complications. A convenient and sensitive method for estimation of lipid peroxide concentration is the quantitative estimation of their metabolic end-product malondialdehyde (MDA) expressed in mmol/L using the thiobarbituric acid test (TBA-test). We have measured the serum concentrations of MDA in 60 well controled type I diabetic patients (28 without retinopathy and 32 with retinopathy) and 13 age-matched healthy subjects. Patients with retinopathy showed significantly increased MDA level (2.65±1.00) compared to diabetics without retinopathy (1.80±0.81) and healthy controls (1.47±0.45). The serum levels of MDA correlated best with glycosylated haemoglobin (r=0.28), serum triglyceride concentration (r=0.29) and serum cholesterol concentration. (r=0.47). Increased lipid peroxides suggesting increased free radical activity is associated with retinopathy and this may have pathogenetic implications.

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Authors and Affiliations

  1. Division of Ophthalmology, University of Alicante, 03690, Alicante, Spain

    M. Losada & J. L. Alio

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  1. M. Losada
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  2. J. L. Alio
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Losada, M., Alio, J.L. Malondialdehyde serum concentration in type 1 diabetic with and without retinopaty. Doc Ophthalmol 93, 223–229 (1997). https://doi.org/10.1007/BF02569062

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  • DOI: https://doi.org/10.1007/BF02569062

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