Zusammenfassung
Diese Arbeit gibt eine Übersicht über die kürzlich entwickelten Tiermodelle, die eine quantitative Einschätzung der Abwehrreaktionen bei noxischen Reizen unterschiedlicher Intensität erlauben. Folgende Modelle werden ausführlich besprochen: a) der „rodent tail flick”-Test und eine Modifikation des Tests, die eine Messung der Kraft sowie der Latenz der Schwanzbewegung ermöglicht, b) die Hinterpfotenflexion der Ratte als Abwehrreflex, die durch thermische Reizung der Pfote ausgelöst wurde, und c) eine erlernte, operante Antwort („nose bar”-Test) durch thermische Reizung des Rattenschwanzes. Diese Modelle werden in Bezug auf ihre Vorteile gegenüber den bisher üblichen Tests diskutiert, in denen lediglich eine Bestimmung der Antwortschwelle erfolgte. Desweiteren wird diskutiert, inwieweit diese neuen Modelle die Kriterien eines idealen Modells zur Schmerzmessung erfüllen, und die neuronalen Grundlagen, die den Verhaltensmustern zugrundeliegen.
Abstract
This paper reviews several recently developed animal models that allow a quantitative assessment of the magnitude of nocifensive behavioral responses across a range of noxious stimulus intensities. Models discussed in detail include: (a) the rodent tail flick reflex, and a modification that allows measurement of tail flick magnitude, (b) rat hindlimb flexion withdrawal reflex elicited by noxious thermal stimulation of the paw, and (c) a learned operant response (nose bar press) evoked by noxious thermal stimulation of the rat’s tail. These models are discussed in terms of their advantages over previous methods measuring response threshold, their fulfillment of criteria for ideal pain assessment models, and the neuronal circuitry underlying the behavioral response.
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Herrn Professor Dr. M. Zimmermann zum 60. Geburtstag gewidmet.
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Carstens, E. Quantitative assessment of nocifensive behavioral responses and the underlying neuronal circuitry. Schmerz 7, 204–215 (1993). https://doi.org/10.1007/BF02529857
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DOI: https://doi.org/10.1007/BF02529857