Abstract
We examined the relationship between cardiac output (CO) and mixed venous-arterialPco 2 gradient (\(\bar v - aPco_2 \)) along with the other variables derived from arterial and/or mixed venous blood gases in sodium bicarbonate-treated dogs. Six dogs with low cardiac output following cardiopulmonary resuscitation were used. CO, blood gases, and hemoglobin measurements were repeated every 20–30 min after administration of sodium bicarbonate or normal saline. All measurements were performed after the confirmation of a steady state of CO2 elimination by end-tidal CO2 monitoring. Arteriovenous oxygen content difference (\(Cao_2 - C\bar vo_2 \)), mixed venous oxygen saturation (\(S\bar vo_2 \)), and\(\bar v - aPco_2 \) were highly correlated with CO. The correlation coefficients between\(Cao_2 - C\bar vo_2 \),\(S\bar vo_2 \), and\(\bar v - aPco_2 \) werer=−0.81 (P<0.001),r=0.70 (P<0.001), andr=−0.77 (P<0.001), respectively. The results suggest that, if\(\bar v - aPco_2 \) is measured during the steady state, except for the period during the transient increase in CO2 elimination just after the administration of sodium bicarbonate,\(\bar v - aPco_2 \) can be used as an index of systemic perfusion even after the administration of sodium bicarbonate.
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Okamoto, K., Kishi, H., Choi, H. et al. Relationship between cardiac output and mixed venous-arterialPco 2 gradient in sodium bicarbonate-treated dogs. J Anesth 8, 204–207 (1994). https://doi.org/10.1007/BF02514714
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DOI: https://doi.org/10.1007/BF02514714