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Effect of a new antitumor drug cycloplatam on DNA structure and production

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The new antitumor drug cycloplatam [amine (cyclopentylamine)-S-(-)-malatoplatinum(II)] caused dose-dependent formation of interstrand DNA ligationsin vitro depending on the duration of incubation. Like cisplatin, cycloplatam caused a deep and long inhibition of DNA production in tumor cells. The effect of cycloplatam in bone marrow and small intestine epithelium cells was weaker and shorter than that of cisplatin.

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Authors and Affiliations

  1. Institute of Biochemical Physics, Russian Academy of Sciences, USSR

    A. G. Tikhomirov, I. S. Sokolova, L. Yu. Dederer & L. B. Gorbacheva

Authors
  1. A. G. Tikhomirov
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  2. I. S. Sokolova
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  3. L. Yu. Dederer
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  4. L. B. Gorbacheva
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 2, pp. 197–199, February, 1998

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Tikhomirov, A.G., Sokolova, I.S., Dederer, L.Y. et al. Effect of a new antitumor drug cycloplatam on DNA structure and production. Bull Exp Biol Med 125, 172–174 (1998). https://doi.org/10.1007/BF02496851

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  • DOI: https://doi.org/10.1007/BF02496851

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