Abstract
From November 1981 to the end of August 1984, 456 patients with breast lesions underwent aspiration biopsy cytology (A.B.C.). This study includes 109 for whom the diagnosis was histologically confirmed at surgical biopsy. Seventy-five lesions were histologically proven to be malignant and 34 were benign. The accuracy of diagnoses with A.B.C. was; true positive 86.7 per cent (65/75) of the time, true negative 82.6 per cent (28/34) of the time, false negative 5.3 per cent (4/75) of the time and false positive 5.7 per cent (2/34) of the time. Unsatisfactory or inadequate aspirated tissue made A.B.C. diagnosis difficult in 5.5 per cent (6/109) of the cases. Three out of 7 with malignant tumors, who were wrongly diagnosed as benign by A.B.C., had tumors with a diameter of 1.0 cm or less. Two benign cases which were falsely diagnosed as malignant also had small tumors about 1.0 cm in diameter. Although A.B.C. is more reliable than other conventional supplementary diagnostic techniques (mammography, ultrasonography, etc.), it is important to carefully follow clinically questionable cases which appear negative, using A.B.C.
Similar content being viewed by others
References
Kreuzer G, Boquoi E. Aspiration biopsy cytology, mammography and clinical exploration: A modern set up in diagnosis of tumor of the breast. Acta Cytol 1976; 20: 319–323.
Stavrić GD, Tevcév DT, Kaftandjiev DR, Novak JJ. Aspiration biopsy cytologic method in diagnosis of breast lesions: A critical review of 250 cases. Acta Cytol 1973; 17: 188–190.
Vorherr H. Breast aspiration biopsy. Am J Obstet Gynecol 1984; 148: 127–133.
Bauermeister DE. The role and limitations of frozen section and needle aspiration biopsy in breast cancer diagnosis. Cancer 1980; 46: 947–949.
Kern WH. The diagnosis of breast cancer by fine-needle aspiration smears. JAMA 1979; 241: 1125–1127.
Rosen P, Hajdu SI, Robbins GF, Foote FW. Diagnosis of carcinoma of the breast by aspiration biopsy. Surg Gyne Obst 1972; 134: 837–838.
Zajdela A, Ghossein NA, Pilleron JP, Ennuyer A. The value of aspiration cytology in the diagnosis of breast cancer: Experience at the Foundation Curie. Cancer 1975; 35: 499–506.
Linsk JA, Franzén S. Clinical aspiration cytology. Philadelphia: JB Lippincott Company, 1983; 105–138.
Japan Mammary Cancer Society: General Rules for Clinical and Pathological Record of Mammary Cancer. Tokyo: Kanehara Shuppan, 1982. (in Japanese).
Martin HE, Ellis EB. Biopsy by needle puncture and aspiration. Ann Surg 1930; 92: 169–181.
Duguid HLD, Wood RAB, Irving AD, Preece PE, Cuschieri A. Needle aspiration of the breast with immediate reporting of material. Br Med J 1979; 2: 185–187.
Franzén S, Zajicek J. Aspiration biopsy in diagnosis of palpable lesions of the breast: Critical review of 3,479 consecutive biopsies. Acta Radiol 1968; 7: 241–262.
Kline TS. Handbook of fine needle aspiration biopsy cytology. St Louis: The CV Mosby Company, 1981; 114–175.
Nishizawa Y, Koyama H, Wada T, Terasawa T, Wada A, Nangumo S, Matsuda M. Needle aspiration cytology in early diagnosis of breast cancer. J Jpn Soc Cancer Ther 1983; 18: 661–665. (in Japanese)
Takeda T, Takaso K, Isono S, Oshiba M, Yoshida K, Ishioka K, Sato E. Studies on cytologic characteristics of mammary aspiration smears based on histological types. Acta Cytol 1977; 21: 424–428.
Wallgren A, Zajicek J. The prognostic value of the aspiration biopsy smear in mammary carcinoma. Acta Cytol 1976; 20: 479–485.
Wilson SL, Ehrmann RL. The cytologic diagnosis of breast aspirations. Acta Cytol 1978; 22: 470–475.
Kline TS, Joshi LP, Neal HS. Fine-needle aspiration of the breast; Diagnosed and Pitfalls: A review of 3,545 cases. Cancer 1979; 44: 1458–1464.
Matsuyama T, Amano K, Yamane M, Ushio H, Nishiki M, Ezaki H. Practice of aspiration biopsy cytology in breast cancer. J Hiroshima Med Assoc 1983; 36: 591–594. (in Japanese)
Berg JW, Robbins GF. A late look at the safety of aspiration biopsy. Cancer 1962; 15: 826–827.
Robbins GF, Brothers III JH, Eberhart WF, Quan S. Is aspiration biopsy of breast cancer dangerous to the patient? Cancer 1954; 7: 774–778.
Bibbo M, Zuspan FP. Fine-needle aspiration of the breast in an obstetrics and gynecology hospital. Am J Obstet Gynecol 1975; 122: 525–526.
Kline TS, Neal HS. Needle aspiration of the breast-Why bother? Acta Cytol 1976; 20: 324–327.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kataoka, T., Nishiki, M., Matsuyama, T. et al. Diagnosis of breast lesions by aspiration biopsy cytology. The Japanese Journal of Surgery 15, 361–367 (1985). https://doi.org/10.1007/BF02469931
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02469931