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Dopaminergic mechanisms of neostriatum in the regulation of adaptive behavior by corticoliberin

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Abstract

A conditioned active avoidance response was developed in rats with high (KHA) and low (KLA) rates of learning and the effects of injection of corticoliberin into the dorsal striatum on orientational-investigative and avoidance behavior were studied in normal animals and after depletion of striatal dopamine by preliminary injection of 6-hydroxydopamine. These studies showed that corticoliberin, like 6-hydroxydopamine, produced similar trends in the animals' behavior. Their effects were mediated by opposite mechanisms in animals with initial active and passive learning strategies for adaptive behavior. The role of dopaminergic structures of the striatum in mediating the behavioral effects of corticoliberin is discussed.

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References

  1. Ya. Buresh, O. Bureshova, and J. Houston,Methods and Basic Experiments in Studies of the Brain and Behavior [in Russian], Vysshaya Shkola, Moscow (1991).

    Google Scholar 

  2. A. I. Gorbachevskaya, N. B. Saul'skaya, and O. G. Chivileva, “The interaction between the nucleus accumbens and the dorsal striatum. Morphological and neurochemical investigations,”Usp. Fiziol. Nauk.,26, No. 1, 107–118 (1994).

    Google Scholar 

  3. Yu. S. Dmitriev and A. A. Bachmanov, “Characteristics of the behavior of rats selected for their learning ability,”Zh. Vyssh. Nerv. Deyat.,42, No. 2, 302–307 (1992).

    Google Scholar 

  4. D. A. Zhukov,the Psychogenetics of Stress. Behavioral and Endocrine Correlates of Genetic Determinants of Stress Reactivity in Non-Controlled Situations [in Russian], St. Petersburg (1997).

  5. N. B. Saul'skaya, “Neurochemical evidence for the interaction of the mesolimbic and nigrostriatal systems in the rat brain,” in:The Striate System and Behavior in Normal Conditions and Pathology [in Russian], nauka, Leningrad (1988).

    Google Scholar 

  6. N. B. Saul'skaya, “Dopamine levels in structures of the nigrostriatal and nigrolimbic systems of the brain in experimental pathology of higher nervous activity in rats,”Zh. Vyssh. Nerv. Deyat.,35, No. 3, 561–564 (1985).

    Google Scholar 

  7. N. B. Saul'skaya, “Regulation by the nucleus accumbens of synaptic dopamine release in the striatum,” in:The Physiology of Mediator Processes [in Russian], Moscow (1990).

  8. E. V. Turkina, E. A. Rybnikova, V. V. Rakitskaya, and V. G. Shalyapina, “Involvement of the neostriatum in regulating the actions of corticoliberin on the hormonal functions of the adrenal glands,”Ros. Fiziol. Zh. im. I. M. Sechenova,82, No. 5–6, 109–112 (1996).

    CAS  Google Scholar 

  9. E. V. Turkina, E. A. Rybnikova, V. V. Rakitskaya, and V. G. Shalyapina, “Changes in the behavioral components of stress by intrastriatal administration of corticoliberin,”Ros. Fiziol. Zh.,83, No. 1–2, 150–156 (1997).

    CAS  Google Scholar 

  10. A. J. Dunn and C. W. Berridge, “Physiological and behavioral responses to CRF administration: is CRF a mediator of anxiety of stress responses?,”Brain Res.,2, 71–153 (1990).

    Google Scholar 

  11. H. C. Fibirger and A. G. Phillips, “Reward, motivation, cognition: psychobiology of mesotelencephalic dopamine systems,” in:Handbook of Physiology: The Nervous System, F. E. Bloom (Ed.) (1986), Vol. IV:Intrinsic Regulatory Systems of the Brain.

  12. G. Koob and F. Bloom, “Corticotropin-releasing factor and behavior,”Fed. Proc.,44, Part 2, 259–263 (1984).

    Google Scholar 

  13. L. J. Pellegrino, A. S. Pellegrino, and A. J. Cushman,A Stereotaxic Atlas of the Rat Brain, New York (1979).

  14. W. Vale, J. Spiess, C. Rivier, and J. Rivier, “Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin secretion,”Science,213, 1394–1397 (1981).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Neuroendocrinology Laboratory, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia

    E. V. Turkina

Authors
  1. V. G. Shalyapina
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  2. E. A. Rybnikova
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  3. V. V. Rakitskaya
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  4. E. V. Turkina
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 84, No. 10, pp. 1146–1151, October, 1998.

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Shalyapina, V.G., Rybnikova, E.A., Rakitskaya, V.V. et al. Dopaminergic mechanisms of neostriatum in the regulation of adaptive behavior by corticoliberin. Neurosci Behav Physiol 30, 147–151 (2000). https://doi.org/10.1007/BF02463152

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  • DOI: https://doi.org/10.1007/BF02463152

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