Abstract
We studied rats with a hemi-Parkinsonian model created by lesions of mesostriatal dopaminergic neurons. Correlation between the extent of lesions and intensity of forced rotation movements (apomorphine (APO)-induced rotations, i.e., exercise) was investigated. The levels of endothelins (ET) in the circulation after rotation under normoxic and hypoxic conditions were measured. In normoxia, the rotation sessions were associated with significant decreases in circulating ET levels, from 21.32±4.06 to 9.32±1.08 pg/ml. Although hypoxia had no effect on the frequency of rotations induced by APO, it significantly attenuated a decrease in the ET levels in the circulation of rats with the most extensive lesions. We suggest that the mesostriatal dopaminergic system modulates endothelial function by an active process. This may have relevance for some clinical manifestations of disordered striatal function observed in humans.
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References
C. W. Olanow, “The potential role of free radicals in the mechanisms of cell death,” in:Proceedings of the 5th Annual Symposium Neurodegenerative Disorders (Keystone, Colorado, March 11–13, 1992), PRO Communications, Greenwich Office Park, Greenwich CT 06831 (1993), pp. 7–9.
C. J. Pycock, “Turning behaviour in animals,”Neuroscience,5, No. 3, 461–514 (1980).
I. J. Mitchell, C. E. Clarke, S. Boyce, et al., “Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,”Neuroscience,32, No. 1, 213–226 (1990).
V. V. Frolkis, O. V. Bazilyuk, and N. V. Sikalo, “Role of endothelium in age-related changes of vessels reactivity to action of physiologically active agents and hypoxia,”Probl. Stareniya Dolgoletiya,3, No. 2, 83–90 (1993).
R. F. Furchgott and T. V. Zawadzki, “The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine,”Nature,288, No. 5789, 373–376 (1980).
S. Moncada and E. A. Higgs, “Molecular mechanisms and therapeutic strategies related to nitric oxide,”FASEB J.,9, 1319–1330 (1995).
R. A. Kelly, J. L. Balligand, and T. W. Smith, “Nitric oxide and cardiac function,”Circ. Res.,79, No. 3, 363–380 (1996).
R. F. O'Brien, R. J. Robbins, and I. F. McMurtry, “Endothelial ceils in culture produce a vasoconstrictor substance,”J. Cell. Physiol.,132, 263–270 (1987).
M. Yanagisawa, H. Kurihara, S. Kimura, et al., “A novel potent vasoconstrictor peptide produced by vascular endothelial cells,”Nature,332, 411–415 (1988).
E. Anggard, S. Galton, G. Rae, et al., “The fate of radioiodinated endothelin-1 and endothelin-3 in the rat,”J. Cardiovascul. Pharmacol., Suppl. 5,13, 46–49 (1989).
S. J. Gibson, D. R. Springall, and J. M. Polak, “Endothelin, a ubiquitous peptide: morphological demonstration of immunoreactive and synthetic sites and receptors in the respiratory tract and central nervous system,” in:Endothelin, G. M. Rubanyi (ed.), Oxford Univ. Press, New York, Oxford, (1992), pp. 179–207.
C. R. Hiley, “Endothelin receptor ligands,”Neurotransmissions,11, No. 2, 1–6 (1995).
W. G. Haynes, “Endothelins as regulators of vascular tone in man,”Clin. Science,88, No. 5, 509–517 (1995).
B. A. Markewitz, D. E. Kohan, and J. R. Michael, “Hypoxia decreases endothelin-1 synthesis by rat lung endothelial cells,”Am. J. Physiol.,269, No. 2, 215–220 (1995).
A. Morganti, M. Giussani, C. Sala, et al., “Effects of exposure to high altitude on plasma endothelin-1 levels in normal subjects,”J. Hypertens.,13, No. 8, 859–865 (1995).
Y. Saito, K. Nakao, M. Mukoyama, and H. Imura, “Increased plasma endothelin level in patients with essential hypertension,”New Engl. J. Med.,322, 205 (1990).
E. Nava and T. F. Luscher, “Endothelium-derived vasoactive factors in hypertension: nitric oxide and endothelin,”J. Hypertens., Suppl.,13, No. 2, 39–48 (1995).
S. Maeda, T. Miyauchi, T. Waku, et al., “Plasma endothelin-1 level in athletes after exercise in a hot environment: exercise-induced dehydration contributes to increases in plasma endothelin-1,”Life Sci., 58, No. 15, 1259–1268 (1996).
P. de Groote, A. Millaire, A. Racadot, et al., “Plasma levels of endothelin-1 at rest and after exercise in patients with moderate congestive heart failure,”Intern. J. Cardiol.,51, No. 3, 267–272 (1995).
V. F. Sagach, A. M. Kindybalyuk, and T. N. Kovalenko, “Functional hyperemia of skeletal muscle: a role of endothelium,”J. Cardiovascul. Pharmacol., Suppl. 12,20, 170–175 (1992).
J. Armt, “Behavioural studies of dopamine receptors: evidence for regional selectivity and receptor multiplicity,” in:Dopamine Receptors, I. Creese and C. A. Fraser (eds.), Alan Liss, New York (1987), pp. 199–231.
V. F. Sagach, N. N. Oleshko, V. A. Maiskii, et al., “Striatal lesions and endothelial function: effects of exercise and hypoxia on circulating endothelins,”Clin. Autonom. Res.,6, Abstr., 275–276 (1996).
L. J. Pellegrino, A. S. Pellegrino, and A. J. Cushman,A Stereotaxic Atlas of the Rat Brain, Plenum Press, New York (1979).
G. Paxinos and C. Watson,The Rat Brain in Stereotaxic Coordinates, Acad. Press, INC, San Diego, California, Acad. Press LIM, Oval Road, London (1986).
T. Saito, M. Yanagisawa, T. Miyauchi, et al., “Endothelin in human circulating blood: effects of major surgical stress,”Jpn. J. Pharmacol.,49, Abstr., 215P (1989).
W. G. Nayler,The Endothelins, Springer-Verlag, Berlin, Heidelberg (1990), pp. 183.
C. Letizia, F. Barillp, S. Cerci, et al., “Dynamic exercise-induces elevation of plasma levels of endothelins-1 in patients with coronary artery disease,”Angiology,49, No. 9, 819–826 (1995).
D. R. Morel, J. S. Lacroix, A. Hemsen, et al., “Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock,”Eur. J. Pharmacol.,167, 427–428 (1989).
J. Pernow, A. Hemsen, and J. M. Lundberg, “Tissue specific distribution, clearance and vascular effects of endothelin in the pig,”Biochem. Biophys. Res. Commun.,161, 647–653 (1989).
T. Yoshizawa, H. Iwamoto, H. Mizusawa, et al., “Cerebrospinal fluid endothelin-1 in Alzheimer's disease and senile dementia of Alzheimer type,”Neuropeptides,22, No. 2, 85–88 (1992).
K. Saliminen, I. Tikkanen, O. Saijonmaa, et al., “Modulation of coronary tone in acute myocardial infarction by endothelin,”Lancet,ii, 747 (1989).
H. Koyama, T. Tabata, Y. Nishzawa, et al., “Plasma endothelin levels in patients with uremia,”Lancet,i, 991 (1989).
E. Hartter, D. H. Petzl, W. Schuller, et al., “Low amounts of endothelin in the circulation of healthy persons at rest and at physical stress,”Am. J. Hypertens.,2, 83P (1989).
O. Appenzeller and E. Martignoni, “The autonomic nervous system and hypoxia: mountain medicine,”J. Autonom. Nerv. Syst.,57, 1–12 (1996).
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Sagach, V.F., Bazilyuk, O.V., Oleshko, N.N. et al. Mesostriatal lesions and endothelial function: Effects of forced movements and hypoxia on levels of circulating endothelins. Neurophysiology 30, 13–18 (1998). https://doi.org/10.1007/BF02463107
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DOI: https://doi.org/10.1007/BF02463107