Abstract
The expression of the early genes c-fos and c-jun were studied by blot hybridization in the central nervous system of the edible snail at the consolidation stage of a conditioned defensive reflex, with the aim of investigating genomic activity in neurons during learning. The c-fos gene was shown to be present in theHelix central nervous system, and its expression was shown to increase significantly during learning. Superinduction of the c-fos gene was observed in the presence of cycloheximide, a protein synthesis inhibitor. Corasol also induced this gene. Thus, induction of the c-fos gene inHelix can be induced by agents which induce it in higher vertebrates. This suggests that expression of the c-fos gene inHelix and in higher vertebrates is regulated by closely related mechanisms. Expression of the c-jun gene was insignificant, and definitive conclusions with regard to the role of this gene in learning cannot be drawn.
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Department of Medical Informatics and Electronics (M. B. Shtark, Director), Construction-Technical Institute of Computer Technology, Siberian Division, Russian Academy of Sciences, Novosibirsk. Translated from Fiziologicheskii Zhurnal im. I. M. Sechenova, Vol. 81, No. 8, pp. 24–28, August, 1996.
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Grinkevich, L.N., Nagibneva, I.N. & Lisachev, P.D. Conditioned defensive reflex in the edible snail (molecular-genetic aspects). Neurosci Behav Physiol 27, 216–220 (1997). https://doi.org/10.1007/BF02462881
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DOI: https://doi.org/10.1007/BF02462881