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Expression of the Fas/APO-1/CD95 antigen mediating apoptosis in human leukemic cells

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The Fas/APO-1 antigen is not detected on peripheral blood leukocytes of patients with chronic myelocytic leukemia in the chronic phase, but is expressed on blast cells in 50% of patients with chronic myelocytic leukemia in blast crisis. The expression of Fas/APO-1 correlates with that of leukocytic CD34 antigen. In patients with lymphomas, acute lymphoblastic leukemia, or acute myeloblastic leukemia some tumor cells carry Fas/APO-1 antigen.

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Authors and Affiliations

  1. Hematology Research Center, Oncology Research Center Russian Academy of Medical Sciences, Moscow

    Yu. V. Shishkin, N. P. Sedyakhina, T. N. Zabotina, S. V. Kuznetsov, A. G. Turkina, T. N. Palkina, E. R. Polosukhina, A. D. Shirin, M. A. Volkova, M. A. Frenkel', N. D. Khoroshko, Z. G. Kadagidze & A. Yu. Baryshnikov

  2. Russian Academy of Medical Sciences, Moscow

    Yu. V. Shishkin, N. P. Sedyakhina, T. N. Zabotina, S. V. Kuznetsov, A. G. Turkina, T. N. Palkina, E. R. Polosukhina, A. D. Shirin, M. A. Volkova, M. A. Frenkel', N. D. Khoroshko, Z. G. Kadagidze & A. Yu. Baryshnikov

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  1. Yu. V. Shishkin
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  2. N. P. Sedyakhina
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  3. T. N. Zabotina
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  4. S. V. Kuznetsov
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  5. A. G. Turkina
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  6. T. N. Palkina
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  7. E. R. Polosukhina
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  8. A. D. Shirin
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  9. M. A. Volkova
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  10. M. A. Frenkel'
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  11. N. D. Khoroshko
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  12. Z. G. Kadagidze
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  13. A. Yu. Baryshnikov
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 11, pp. 544–546, November, 1996

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Shishkin, Y.V., Sedyakhina, N.P., Zabotina, T.N. et al. Expression of the Fas/APO-1/CD95 antigen mediating apoptosis in human leukemic cells. Bull Exp Biol Med 122, 1122–1124 (1996). https://doi.org/10.1007/BF02447664

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  • DOI: https://doi.org/10.1007/BF02447664

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